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Göttingen Minipigs in Ocular Research.

Stephanie M Shrader1, William F Greentree1

  • 11 Charles River Laboratories, Spencerville, Ohio, USA.

Toxicologic Pathology
|April 24, 2018
PubMed
Summary

Göttingen minipigs are valuable nonrodent models for eye research due to their human-like ocular anatomy and ease of handling. They are used in studies on therapeutics, glaucoma, and surgical procedures, employing advanced diagnostic imaging techniques.

Keywords:
drug developmentminipigocularpreclinical safety assessment/risk managementtoxicity

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Area of Science:

  • Biomedical Research
  • Ophthalmology
  • Animal Models

Background:

  • Göttingen minipigs have been utilized in biomedical research since the 1960s.
  • Their suitability for ocular studies stems from ease of handling, manageable size, well-documented genetics, and ocular anatomy resembling humans.
  • This positions them as a key nonrodent model in ophthalmology.

Purpose of the Study:

  • To review the diverse applications of Göttingen minipigs in current ocular research.
  • To provide an overview of the diagnostic methods employed in these studies.
  • To highlight the utility of this animal model for advancing eye research.

Main Methods:

  • Review of existing literature on Göttingen minipig ocular research.
  • Identification of common research areas including therapeutic safety/efficacy, glaucoma, biomaterials, and surgical procedures.
  • Cataloging of in vivo diagnostic techniques used, such as electroretinography, optical coherence tomography, funduscopy, and fluorescein angiography.

Main Results:

  • Göttingen minipigs are extensively used in ocular research covering therapeutic evaluations, glaucoma studies, biomaterial testing, and surgical innovations.
  • A range of advanced in vivo diagnostic tools are routinely applied in conjunction with traditional histopathology.
  • These methods facilitate comprehensive assessment in ocular research using this model.

Conclusions:

  • Göttingen minipigs serve as an effective animal model for a wide spectrum of ocular research.
  • The integration of advanced diagnostic modalities enhances the depth and scope of studies.
  • This model is crucial for investigating ocular diseases and testing novel interventions.