Related Experiment Video

Updated: Feb 11, 2026

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment
05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

Published on: March 11, 2021

5.1K

Role of Inflammatory Markers in Elderly Type 2 Diabetic Patients with Mild Cognitive Impairment

Salwa S Hosny1, Ahmed M Bahaaeldin1, Mohamed S Khater2

  • 1Department of Internal Medicine and Endocrinology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Current Diabetes Reviews
|April 24, 2018
PubMed
Abstract

Insights

Elderly individuals with type 2 diabetes and mild cognitive impairment show elevated levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP). These markers indicate increased inflammation and may contribute to cognitive decline in this population.

Area of Science:

  • Endocrinology
  • Neurology
  • Immunology

Background:

  • Type 2 diabetes (T2DM) is a known risk factor for Alzheimer's disease and mild cognitive impairment (MCI).
  • The exact causes of cognitive impairment in T2DM patients are unclear, but factors like chronic hyperglycemia, microvascular disease, and inflammation are implicated.

Purpose of the Study:

  • To investigate serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP).
  • To compare these levels in elderly T2DM patients with and without MCI, and with healthy controls.

Main Methods:

  • A study involving 90 elderly subjects (≥60 years) divided into three groups: T2DM with MCI, T2DM without cognitive impairment, and healthy controls.
  • Participants underwent clinical evaluation, cognitive assessment (ACE-III), and laboratory tests including glucose, HbA1c, lipid profile, and inflammatory markers (sVCAM-1, hs-CRP).

Main Results:

  • Serum sVCAM-1 levels were significantly higher in T2DM patients with MCI compared to T2DM patients without MCI and controls (P=0.002).
  • Serum hs-CRP levels were also significantly elevated in T2DM patients with MCI compared to the other two groups (P=0.005).

Conclusions:

  • Elderly T2DM patients with MCI exhibit higher concentrations of soluble adhesion molecules and markers of low-grade systemic inflammation.
  • These findings suggest a link between inflammation, vascular adhesion molecules, and cognitive impairment in type 2 diabetes.
Keywords:
Diabetes mellituselderlyhighly sensitive c-reactive proteininflammatory markersmild cognitive impairmentsoluble vascular adhesion molecule.

More Related Videos

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

8.1K
Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment06:48

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment

Published on: June 25, 2019

9.8K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.1K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.5K
Cognitive Dissonance01:38

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Piaget's Stage 2 of Cognitive Development01:14

Piaget's Stage 2 of Cognitive Development

The preoperational stage, the second of Jean Piaget's four stages of cognitive development, spans approximately ages 2 to 7 and is characterized by the emergence of symbolic thinking. During this stage, children use language, images, and symbols to represent objects and concepts, enabling them to engage in imaginative and pretend play. This symbolic thinking supports children's ability to perform make-believe actions, such as imagining a broom as a horse or their hand as a phone, blending...
977
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
17.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.7K