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Azilsartan and Chlorthalidone-new Powerful Fixed dose Antihypertensive Combination

Vasiliki Katsi1, Eleni Athanasiadi1, Costas Tsioufis1

  • 11st Cardiology Department, Athens Medical School, University of Athens, "Hippokration" Hospital, Athens, Greece.

Current Hypertension Reviews
|April 24, 2018
PubMed

Insights

Azilsartan combined with chlorthalidone offers a superior antihypertensive effect compared to individual drugs or other common treatments. This combination is crucial for managing high blood pressure and reducing cardiovascular risks.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Arterial hypertension affects one-third of US adults, with only 54% controlled, costing $46 billion annually.
  • High blood pressure significantly increases the risk of stroke and myocardial infarction worldwide.
  • Novel therapeutic strategies for hypertension management are urgently needed.

Purpose of the Study:

  • To evaluate the efficacy and safety of the azilsartan-chlorthalidone combination.
  • To compare this combination against other widely used antihypertensive options.
  • To review the latest findings on the clinical utility and adverse events of this combination therapy.

Main Methods:

  • Review of recent clinical trials and scientific literature.
  • Comparative analysis of azilsartan and chlorthalidone efficacy versus established antihypertensives.
  • Assessment of safety profiles and adverse event data for the combination therapy.

Main Results:

  • Both azilsartan and chlorthalidone demonstrate superior antihypertensive effects individually compared to certain alternatives.
  • The combination of azilsartan and chlorthalidone exhibits enhanced efficacy in blood pressure reduction.
  • Evidence suggests a favorable safety profile for the combination therapy.

Conclusions:

  • The azilsartan-chlorthalidone combination represents a significant advancement in hypertension treatment.
  • This combination offers a potent and potentially safer option for managing arterial hypertension.
  • Further clinical research may solidify its role as a first-line or adjunctive therapy.

Keywords:
Azilsartan medoxomilchlorthalidonecombinationhypertensionmyocardial infarctionstroke.

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