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Daylight photodynamic therapy for field cancerization: lessons from molecular biology

Max Rybarski1, Lutz Schmitz2, Ben Novak1

  • 1Department of Animal Physiology, Ruhr-University, Bochum, Germany.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|April 24, 2018
PubMed

Insights

Predicting aggressive actinic keratoses (AKs) is challenging. Molecular biology insights may help identify high-risk AK lesions for tailored treatments, improving patient outcomes.

Area of Science:

  • Dermatology
  • Oncology
  • Molecular Biology

Background:

  • Actinic keratoses (AKs) are precursors to squamous cell carcinoma with unpredictable metastatic potential.
  • Field-directed treatments like photodynamic therapy (PDT) are standard for widespread AKs.
  • Conventional PDT (cPDT) is effective but painful; Daylight PDT (dPDT) offers a less painful alternative.

Purpose of the Study:

  • To explore molecular biology of AKs for improved risk stratification.
  • To develop methods for identifying AKs with aggressive behavior.
  • To facilitate personalized treatment strategies for high-risk patients.

Main Methods:

  • Review of current clinical and histological limitations in AK risk assessment.
  • Exploration of molecular markers for AK aggressiveness.
  • Proposed development of a molecular risk profiling tool.

Main Results:

  • Current clinical and histological factors are insufficient for predicting AK invasiveness.
  • Molecular biology offers a promising avenue for risk assessment.
  • A molecular approach could differentiate high-risk AKs.

Conclusions:

  • Molecular profiling is essential for accurate AK risk assessment.
  • Identifying aggressive AKs will enable targeted therapies.
  • This approach can optimize treatment and reduce metastasis risk.

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