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Psoriasis as a cardiovascular risk factor: updates and algorithmic approach.

Emanuele Cozzani1, Gian Marco Rosa2, Martina Burlando3

  • 1Department of Dermatology, San Martino Policlinic, University of Genoa, Genoa, Italy - emanuele.cozzani@unige.it.

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Summary
This summary is machine-generated.

Psoriasis patients, especially those with severe disease, face higher cardiovascular risks due to chronic inflammation and oxidative stress. Early screening for cardiovascular markers is crucial for managing this increased risk.

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Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis is a chronic inflammatory skin disease linked to increased cardiovascular disease (CVD) risk.
  • Patients with moderate to severe psoriasis experience higher rates of cardiovascular mortality, myocardial infarction, and stroke.

Purpose of the Study:

  • To review the link between psoriasis and cardiovascular risk.
  • To explore pathogenic mechanisms connecting psoriasis and atherosclerosis.
  • To discuss serological markers and therapeutic implications for CVD risk in psoriasis patients.

Main Methods:

  • Literature review focusing on the relationship between psoriasis and cardiovascular disease.
  • Analysis of pathogenic pathways including chronic inflammation, oxidative stress, and endothelial dysfunction.
  • Examination of cardiovascular risk factors, genetic background, and medication effects.

Main Results:

  • Chronic inflammation, oxidative stress, and endothelial dysfunction are key links between psoriasis and CVD.
  • Under-diagnosed cardiovascular risk factors are common in psoriasis patients.
  • Specific biomarkers like N-terminal pro B-type natriuretic peptide, homocysteine, and YKL-40 can identify high-risk individuals.

Conclusions:

  • Psoriasis is associated with a significant increase in cardiovascular risk, driven by shared inflammatory pathways.
  • Early detection and management of cardiovascular risk factors and complications are essential for psoriasis patients.
  • A proposed screening flowchart for dermatologists aims to improve cardiovascular risk assessment in psoriasis patients.