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Hippocampal-related memory network in multiple sclerosis: A structural connectivity analysis.

Sara Llufriu1, Maria A Rocca2, Elisabetta Pagani3

  • 1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy/Center of Neuroimmunology, Service of Neurology, Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Casanova, Barcelona, Spain.

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PubMed
Summary
This summary is machine-generated.

Structural connectivity in the memory network is impaired in multiple sclerosis (MS) patients, affecting information transmission and correlating with memory performance. This highlights the importance of structural integrity for memory in MS.

Keywords:
Episodic memoryMRIgraph theoryhippocampusmultiple sclerosisstructural connectivity

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Area of Science:

  • Neuroimaging
  • Network Neuroscience
  • Clinical Neurology

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system.
  • Episodic memory deficits are common in MS patients.
  • Structural connectivity alterations in memory networks may underlie cognitive impairment in MS.

Purpose of the Study:

  • To quantify structural connectivity of the hippocampal-related episodic memory network in MS patients using graph theory.
  • To investigate the association between network properties and memory performance in MS.

Main Methods:

  • Acquired diffusion and T1-weighted MRI from 71 MS patients and 50 healthy controls (HCs).
  • Used probabilistic tractography to create connectivity matrices from 30 gray matter regions.
  • Calculated global, nodal, and edge graph theoretical properties; assessed verbal and visuospatial memory.

Main Results:

  • MS patients exhibited decreased network strength, assortativity, transitivity, global efficiency, and increased average path length compared to HCs.
  • Widespread reductions in streamline count (SC) and edge communicability were observed in MS patients.
  • Poorer memory performance correlated with reduced network efficiency, decreased right hippocampus strength, and altered SC/communicability in key memory-related regions.

Conclusions:

  • Structural connectivity of the hippocampal-related memory network is impaired in MS, leading to reduced information transmission efficiency.
  • Network connectivity metrics are significantly associated with episodic memory performance in MS.
  • Maintaining structural integrity of neural networks is crucial for preserving memory function in individuals with MS.