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Mycophenolate mofetil therapy in adult patients with recalcitrant atopic dermatitis

David Dias-Polak¹, Reuven Bergman^1,2, Emily Avitan-Hersh^1,2

¹a Department of Dermatology, Rambam Health Care Campus , Technion - Israel Institute of Technology , Haifa , Israel.

The Journal of Dermatological Treatment

|April 24, 2018

Abstract

Background:

Patients with severe atopic dermatitis (AD) may require potent immunosuppressive therapy to control their disease. Mycophenolate mofetil (MMF) has been suggested as a safe and effective drug in these cases.

Objectives:

To investigate effectiveness and tolerability of oral MMF in adult patients with severe recalcitrant AD.

Methods:

During the years 2010-2017 oral MMF 2-3 g/day was administered to adult patients with severe recalcitrant AD who failed other major systemic drugs, or where other drugs, including cyclosporine (CSA), methotrexate, and azathioprine, were contraindicated.

Results:

Of 9 consecutive adult patients, 4 (44%) responded completely, 2 (22%) had partial response, and 3 (33%) did not respond at all. The MMF therapy was continued for 5-36 months (average 21 months) without major side effects.

Conclusions:

Oral MMF may be an effective drug in AD. Due to its good safety profile, it may be recommended as a first-line systemic therapy, or successive to CSA in the long term.

Keywords:

Atopic dermatitis mycophenolate mofetil recalcitrant

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