Related Experiment Video

Updated: Feb 11, 2026

Imaging Mismatch Repair and Cellular Responses to DNA Damage in Bacillus subtilis
10:28

Imaging Mismatch Repair and Cellular Responses to DNA Damage in Bacillus subtilis

Published on: February 8, 2010

11.8K

DNA Repair Deficiency and Immunotherapy Response

Kent W Mouw1, Alan D D'Andrea1

  • 1Kent W. Mouw, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Boston, MA; and Alan D. D'Andrea, Dana-Farber Cancer Institute, Boston, MA.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|April 24, 2018
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

11.2K
Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

2.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

Imaging Mismatch Repair and Cellular Responses to DNA Damage in Bacillus subtilis
10:28

Imaging Mismatch Repair and Cellular Responses to DNA Damage in Bacillus subtilis

Published on: February 8, 2010

11.8K
Visualization of DNA Repair Proteins Interaction by Immunofluorescence
07:55

Visualization of DNA Repair Proteins Interaction by Immunofluorescence

Published on: June 26, 2020

11.2K
Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration
08:41

Author Spotlight: Deciphering the Role of ATM in Ataxia-Telangiectasia and the Associated Cerebellar Degeneration

Published on: December 27, 2024

2.0K

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

33.9K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.9K
Overview of DNA Repair02:25

Overview of DNA Repair

9.9K
9.9K
Base-pairing and DNA Repair02:27

Base-pairing and DNA Repair

93.7K
93.7K
Mismatch Repair01:36

Mismatch Repair

43.8K
Overview
43.8K
Base Excision Repair01:54

Base Excision Repair

26.4K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.4K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

40.9K
Overview
40.9K

Articles linked to this work by shared authors, journal, and citation graph.

Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial.

JAMA network open·2026

PTEN deficiency confers sensitivity to ATR inhibitor-based treatment in high-grade serous ovarian cancer.

The Journal of clinical investigation·2026

Genomic analysis of BCG unresponsive non-muscle-invasive bladder cancer identifies drivers of sensitivity to intravesical Gemcitabine/Docetaxel.

bioRxiv : the preprint server for biology·2026

Tumor B-cell infiltration in platinum-treated advanced muscle-invasive urothelial carcinoma.

Molecular oncology·2026

USP1 inhibition promotes RAD18-dependent PCNA degradation and BRCA1 synthetic lethality.

bioRxiv : the preprint server for biology·2026

KDM6 Enzymes are the Mechanistic Targets of Mutant IDH that Dictate Replication Stress Sensitivity.

bioRxiv : the preprint server for biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us