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Cognitive function in manics with associated neurologic factors.

A L Hoff1, S Shukla, B L Cook

  • 1Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8101.

Journal of Affective Disorders
|May 1, 1988
PubMed
Summary

This study found that neurologic factors significantly impact mania, leading to greater cognitive dysfunction and a worse psychiatric illness course in patients with neurologic manias (NM) compared to primary manias (PM). Cognitive testing may help diagnose this subgroup.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Mania is often viewed as a homogeneous condition.
  • Preliminary evidence suggests medical, pharmacological, and neurological factors can precede manic syndromes.
  • Existing diagnostic criteria (DSM-III) suggest mild cognitive impairment in these cases, but this lacks empirical documentation.

Purpose of the Study:

  • To investigate cognitive differences between bipolar patients with neurological antecedents (neurologic manics, NM) and those without (primary manics, PM).
  • To determine if neuropsychological testing can serve as an adjunctive diagnostic tool for identifying NM subgroups.
  • To compare intellectual functioning and psychiatric illness course between NM and PM groups.

Main Methods:

  • Comparison of bipolar patients categorized as NM or PM.

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  • Standardized neuropsychological assessments.
  • Evaluation of clinical parameters and psychiatric illness course.

    • Main Results:

    • The NM group exhibited greater intellectual dysfunction compared to the PM group.
    • The NM group also showed a more severe course of psychiatric illness.
    • Neuropsychological testing revealed significant differences between the two manic subgroups.

    Conclusions:

    • Manic syndromes are not homogeneous and can be influenced by neurological factors.
    • Cognitive deficits and a more severe illness course are associated with neurologic manias.
    • Neuropsychological testing is a valuable adjunctive tool for differentiating subgroups within bipolar disorder, specifically identifying neurologic manias.