Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive function in manics with associated neurologic factors.

A L Hoff1, S Shukla, B L Cook

  • 1Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8101.

Journal of Affective Disorders
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrated experimental and computational evaluation of novel benzopyran-2-one congeners as reactive oxygen species scavengers in inflammation.

Computers in biology and medicine·2026
Same author

Comparing artificial intelligence and multidisciplinary tumor board decision making in real-world cancer care: a prospective blinded concordance study.

ESMO real world data and digital oncology·2026
Same author

Precision Measurement of Neutrino Oscillation Parameters with 10 Years of Data from the NOvA Experiment.

Physical review letters·2026
Same author

Dual-Baseline Search for Active-to-Sterile Neutrino Oscillations in NOvA.

Physical review letters·2025
Same author

Search for CP-Violating Neutrino Nonstandard Interactions with the NOvA Experiment.

Physical review letters·2024
Same author

Additional use of extrinsic warmer for intravenous CT contrast media and its impact on incidence of contrast extravasations and allergic like reactions: a prospective observational case control study.

Clinical radiology·2024
Same journal

The longitudinal relationship between co-rumination and depressive symptoms in adolescents: A systematic review and meta-analytic structural equation modeling.

Journal of affective disorders·2026
Same journal

Child-experienced discrimination and parent mental health in Latino families.

Journal of affective disorders·2026
Same journal

Suicide risk prediction and analysis of associated factors among high school students in four provinces of China based on explainable machine learning.

Journal of affective disorders·2026
Same journal

Integrating hypertriglyceridemia, inflammation, and β-cell stress in clozapine- and olanzapine-associated pancreatitis.

Journal of affective disorders·2026
Same journal

Exploring the functioning trajectories and associated factors in adolescents with first-diagnosis major depressive disorder: Evidence from the sBEAD cohort.

Journal of affective disorders·2026
Same journal

Effects of a self-directed cognitive behavioral therapy manual on depressive symptoms among youths incarcerated for drug-related offenses.

Journal of affective disorders·2026
See all related articles

This study found that neurologic factors significantly impact mania, leading to greater cognitive dysfunction and a worse psychiatric illness course in patients with neurologic manias (NM) compared to primary manias (PM). Cognitive testing may help diagnose this subgroup.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Mania is often viewed as a homogeneous condition.
  • Preliminary evidence suggests medical, pharmacological, and neurological factors can precede manic syndromes.
  • Existing diagnostic criteria (DSM-III) suggest mild cognitive impairment in these cases, but this lacks empirical documentation.

Purpose of the Study:

  • To investigate cognitive differences between bipolar patients with neurological antecedents (neurologic manics, NM) and those without (primary manics, PM).
  • To determine if neuropsychological testing can serve as an adjunctive diagnostic tool for identifying NM subgroups.
  • To compare intellectual functioning and psychiatric illness course between NM and PM groups.

Main Methods:

  • Comparison of bipolar patients categorized as NM or PM.

Related Experiment Videos

  • Standardized neuropsychological assessments.
  • Evaluation of clinical parameters and psychiatric illness course.

    • Main Results:

    • The NM group exhibited greater intellectual dysfunction compared to the PM group.
    • The NM group also showed a more severe course of psychiatric illness.
    • Neuropsychological testing revealed significant differences between the two manic subgroups.

    Conclusions:

    • Manic syndromes are not homogeneous and can be influenced by neurological factors.
    • Cognitive deficits and a more severe illness course are associated with neurologic manias.
    • Neuropsychological testing is a valuable adjunctive tool for differentiating subgroups within bipolar disorder, specifically identifying neurologic manias.