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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Atrial fibrillation in patients with inherited cardiomyopathies

Cynthia Yeung1, Andres Enriquez1, Laiden Suarez-Fuster1

  • 1Kingston General Hospital, Queen's University, Kingston, ON, Canada.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|April 24, 2018
PubMed

Insights

Atrial fibrillation (AF) complicates inherited cardiomyopathies, worsening outcomes. Managing AF in these patients is challenging due to disease-specific factors and cardiac changes.

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Inherited cardiomyopathies frequently present with or develop atrial fibrillation (AF).
  • The unique pathophysiology of each cardiomyopathy influences AF development and maintenance.
  • AF signifies a critical disease stage, increasing morbidity and mortality.

Purpose of the Study:

  • To review the current understanding of AF in inherited cardiomyopathies.
  • To explore the prevalence, pathophysiology, risk factors, and treatment of AF.
  • To focus on hypertrophic cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy, familial dilated cardiomyopathy, and left ventricular non-compaction cardiomyopathy.

Main Methods:

  • Literature review of current information on AF in inherited cardiomyopathies.
  • Analysis of disease-specific defects and cardiac chamber changes.
  • Examination of treatment challenges in this patient population.

Main Results:

  • AF is a common complication with significant prognostic implications.
  • Pathogenesis of AF is multifactorial, involving genetic defects and structural heart changes.
  • AF management is complex and requires tailored approaches.

Conclusions:

  • AF significantly impacts the clinical course and prognosis of inherited cardiomyopathies.
  • Understanding the interplay between cardiomyopathy type and AF is crucial for effective management.
  • Further research is needed to optimize AF treatment strategies in these complex patients.

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