Related Experiment Video

Updated: Feb 11, 2026

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread
05:23

Author Spotlight: Decoding Metastasis-to-Metastasis Seeding Using a New In Vivo Technique for Tracking Breast Cancer Spread

Published on: July 7, 2023

1.6K

Systemic Treatment Options for Brain Metastases from Non-Small-Cell Lung Cancer

Ajaz Bulbul, Patrick M Forde, Ayesha Murtuza

    Oncology (Williston Park, N.Y.)
    |April 24, 2018
    PubMed

    Insights

    Brain metastases are a significant challenge in non-small-cell lung cancer (NSCLC). Targeted therapies and immunotherapies show promise for improving outcomes in patients with brain metastases.

    Area of Science:

    • Oncology
    • Neurology
    • Pharmacology

    Background:

    • Brain metastases frequently occur in non-small-cell lung cancer (NSCLC) patients.
    • Limited treatment options and poor prognosis highlight the need for novel therapeutic strategies.

    Purpose of the Study:

    • To review recent advancements in treating NSCLC brain metastases.
    • To discuss the role of targeted therapies and immunotherapies in improving central nervous system outcomes.

    Main Methods:

    • Review of current literature on targeted therapies and immunotherapies for NSCLC brain metastases.
    • Analysis of novel compounds demonstrating blood-brain barrier permeability.
    • Integration of findings with advancements in radiation techniques.

    Main Results:

    • Targeted therapies for EGFR- and ALK-dependent NSCLC show blood-brain barrier penetration.
    • These therapies have led to significant improvements in central nervous system outcomes.
    • Oncogene-driven tumor therapies and immunotherapies demonstrate promise in clinical studies.

    Conclusions:

    • Emerging targeted therapies and immunotherapies are transforming treatment paradigms for NSCLC brain metastases.
    • Combined with advanced radiation techniques, these approaches offer improved prognosis.
    • Further research is crucial for optimizing treatment strategies and patient outcomes.

    More Related Videos

    Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases09:48

    Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

    Published on: August 23, 2024

    811
    Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells08:47

    Improved Visualization of Lung Metastases at Single Cell Resolution in Mice by Combined In-situ Perfusion of Lung Tissue and X-Gal Staining of lacZ-Tagged Tumor Cells

    Published on: August 21, 2012

    17.8K

    Related Concept Videos

    Treatment Resistant Cancers02:56

    Treatment Resistant Cancers

    Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
    3.8K
    Functional Brain Systems: Limbic System01:15

    Functional Brain Systems: Limbic System

    The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
    7.5K
    Functional Brain Systems: Reticular Formation01:13

    Functional Brain Systems: Reticular Formation

    The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
    Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
    5.0K
    Lung Capacity01:47

    Lung Capacity

    The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
    56.4K
    Second Order systems II01:18

    Second Order systems II

    In an underdamped second-order system, where the damping ratio ζ is between 0 and 1, a unit-step input results in a transfer function that, when transformed using the inverse Laplace method, reveals the output response. The output exhibits a damped sinusoidal oscillation, and the difference between the input and output is termed the error signal. This error signal also demonstrates damped oscillatory behavior. Eventually, as the system reaches a steady state, the error diminishes to zero.
    412
    First Order Systems01:21

    First Order Systems

    First-order systems, such as RC circuits, are foundational in understanding dynamic systems due to their straightforward input-output relationship. Analyzing their responses to different input functions under zero initial conditions reveals significant insights into system behavior.
    When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
    435