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[Correlation between breast development and hormone profiles in puberal girls]
M Murakami1, K Kawai, K Higuchi
1Department of Obstetrics and Gynecology, Showa University School of Medicine, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi
|May 1, 1988
Summary
Pubertal breast development correlates with hormone levels, particularly dehydroepiandrosterone-sulfate (DHA-S). Increased height, weight, and DHA-S are linked to advanced breast stages in girls.
Area of Science:
- Endocrinology
- Human Physiology
- Pediatric Development
Context:
- Puberty involves significant physiological changes, including breast development.
- Hormonal fluctuations play a critical role in pubertal maturation.
- Understanding these changes is crucial for assessing normal development.
Purpose:
- To investigate the relationship between serum hormone levels and breast development stages in pubertal girls.
- To identify specific hormones that correlate with breast maturation.
- To explore the role of adrenal steroids, like dehydroepiandrosterone-sulfate (DHA-S), in this process.
Summary:
- Serum hormone levels (LH, FSH, E2, DHA, DHA-S, T) and physical measurements (height, weight) were analyzed in 162 girls (9-17 years).
- Breast development stages (Tanner B1-B5) showed positive correlations with height, weight, and several hormones, notably DHA-S.
- A significant positive correlation was found between DHA-S, body weight, and breast development stage, both before and after menarche.
Impact:
- Suggests an intimate relationship between breast development and steroid hormone concentrations, especially DHA-S.
- Highlights DHA-S as a key indicator in assessing pubertal breast maturation.
- Provides insights into the endocrine regulation of female pubertal development.