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Vascular smooth muscle cell proliferation as a therapeutic target. Part 1: molecular targets and pathways

Dongdong Wang1, Pavel Uhrin2, Andrei Mocan3

  • 1Department of Molecular Biology, Institute of Genetics and Animal Breeding of the Polish Academy of Sciences, ul. Postepu 36A, Jastrzębiec, 05-552 Magdalenka, Poland; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria; Institute of Clinical Chemistry, University Hospital Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland.

Biotechnology Advances
|April 24, 2018
PubMed

Insights

Excessive vascular smooth muscle cell proliferation drives cardiovascular diseases. Understanding the complex signaling pathways regulating this process is key to developing new vascular therapies.

Area of Science:

  • Cardiovascular biology
  • Cell signaling
  • Vascular medicine

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Vascular smooth muscle cell (VSMC) proliferation is a critical factor in atherosclerosis, restenosis, and pulmonary hypertension.
  • The regulation of VSMC proliferation involves intricate molecular signaling networks.

Purpose of the Study:

  • To review the significance of signaling cascades in regulating vascular cell proliferation.
  • To highlight the importance of understanding these mechanisms for therapeutic development.

Main Methods:

  • Literature review and synthesis of existing research on VSMC proliferation signaling.
  • Recapitulation of key signaling pathways involved in vascular cell growth regulation.

Main Results:

  • Signaling pathways controlling vascular cell proliferation are complex and multifactorial.
  • Dysregulation of these pathways contributes to the pathogenesis of major cardiovascular diseases.

Conclusions:

  • A comprehensive understanding of vascular cell proliferation mechanisms is crucial.
  • This knowledge is essential for identifying novel therapeutic targets, including natural products, for cardiovascular conditions.
Keywords:
AtherosclerosisCardiovascular diseasesCell cycleProliferationPulmonary hypertensionRestenosisSignaling pathwayVascular smooth muscle cells

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