Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phosphate Buffer01:22

Phosphate Buffer

5.4K
The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
5.4K
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

1.3K
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
1.3K
Toxic Reactions: Overview01:26

Toxic Reactions: Overview

2.1K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.1K
The Soil Ecosystem02:23

The Soil Ecosystem

25.0K
Plants obtain inorganic minerals and water from the soil, which acts as a natural medium for land plants. The composition and quality of soil depend not only on the chemical constituents but also on the presence of living organisms. In general, soils contain three major components:
25.0K
Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
Predator-Prey Interactions02:39

Predator-Prey Interactions

21.7K
Predators consume prey for energy. Predators that acquire prey and prey that avoid predation both increase their chances of survival and reproduction (i.e., fitness). Routine predator-prey interactions elicit mutual adaptations that improve predator offenses, such as claws, teeth, and speed, as well as prey defenses, including crypsis, aposematism, and mimicry. Thus, predator-prey interactions resemble an evolutionary arms race.
21.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cofactor functions of magnesium in complement activation and antimicrobial responses.

Expert review of clinical immunology·2026
Same author

Vitamin D-AMP axis in host defense against fungal infections.

Frontiers in nutrition·2026
Same author

Phosphate-Mediated Regulation of Intracellular Calcium Dynamics.

Cells·2026
Same author

Phosphorus Intake and Cancer Risk: A Theoretical-Conceptual Model and Hypothesis for Population-Study Replication.

Nutrients·2026
Same author

Response: "Letter to the Editor: Lessons to Be Learned From the COVID-19 Pandemic: Some Further Ideas".

International journal of public health·2026
Same author

NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma.

Cell reports·2026

Related Experiment Video

Updated: Feb 11, 2026

Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products
05:27

Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products

Published on: December 25, 2016

15.6K

Phosphate toxicity and tumorigenesis.

Ronald B Brown1, Mohammed S Razzaque2

  • 1School of Public Health & Health Systems, University of Waterloo, Waterloo, Ontario, Canada.

Biochimica Et Biophysica Acta. Reviews on Cancer
|April 24, 2018
PubMed
Summary

Cellular phosphate burden drives cancer growth, with tumor cells accumulating more phosphate. High dietary phosphate intake correlates with increased tumor development and progression, suggesting phosphate metabolism as a therapeutic target.

Keywords:
DietFGF23KlothoPhosphate toxicityTumorigenesis

More Related Videos

Measuring RAN Peptide Toxicity in C. elegans
10:49

Measuring RAN Peptide Toxicity in C. elegans

Published on: April 30, 2020

7.1K
Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals
08:54

Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals

Published on: May 25, 2016

8.9K

Related Experiment Videos

Last Updated: Feb 11, 2026

Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products
05:27

Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products

Published on: December 25, 2016

15.6K
Measuring RAN Peptide Toxicity in C. elegans
10:49

Measuring RAN Peptide Toxicity in C. elegans

Published on: April 30, 2020

7.1K
Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals
08:54

Synthesis and Exfoliation of Discotic Zirconium Phosphates to Obtain Colloidal Liquid Crystals

Published on: May 25, 2016

8.9K

Area of Science:

  • Oncology
  • Cell Biology
  • Metabolic Research

Background:

  • Cellular phosphate accumulation is a key factor in cancer development.
  • Tumor cells exhibit altered phosphate transport and homeostasis compared to normal cells.
  • Dysregulated phosphate metabolism is linked to the initiation and progression of various human cancers.

Purpose of the Study:

  • To summarize evidence linking cellular phosphate burden to cancer cell growth.
  • To explore the role of phosphate homeostasis in tumor genesis and progression.
  • To highlight the potential of modulating phosphate metabolism as a cancer therapeutic strategy.

Main Methods:

  • Review of existing scientific literature and epidemiological studies.
  • Analysis of experimental animal models demonstrating tumor growth with high phosphate diets.
  • Examination of cellular mechanisms, including phosphate cotransporters and signaling pathways.

Main Results:

  • Tumor cells show increased phosphate cotransporter expression and intracellular phosphate storage.
  • High dietary phosphate intake promotes lung and skin tumor growth in animal models.
  • Excessive phosphate burden is associated with growth signaling, neovascularization, metastasis, and chromosome instability.
  • Epidemiological data links high dietary phosphate to lethal and high-grade prostate cancer.

Conclusions:

  • Cellular phosphate burden is a critical determinant in cancer cell pathophysiology.
  • Further research is needed to understand phosphate's role in tumorigenesis and metastasis.
  • Modulating phosphate metabolism may offer a novel therapeutic approach for cancer treatment and improving patient outcomes.