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Cementum regeneration using stem cells in the dog model: A systematic review
Jacqueline Crossman1, Maryam Elyasi1, Tarek El-Bialy1
1School of Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Archives of Oral Biology
|April 24, 2018
Summary
Stem cell therapy shows promise for regenerating lost cementum, crucial for preventing tooth loss from periodontitis. However, further research is needed to clarify the specific effects of different stem cell types and transplantation methods in dogs.
Area of Science:
- Periodontology
- Regenerative Medicine
- Stem Cell Biology
Background:
- Restoring lost periodontal tissues, including cementum, is vital for preventing tooth loss caused by periodontitis and root resorption.
- Stem cell therapy presents a promising regenerative strategy for cementum regeneration.
Purpose of the Study:
- To systematically review the effects of various stem cells and transplantation methods on cementum regeneration.
- To analyze cementum regeneration in the canine model.
Main Methods:
- Comprehensive literature search including electronic databases, hand searches, and gray literature.
- Inclusion criteria applied to titles and abstracts, followed by full-text selection.
- Data extraction and risk of bias assessment for individual studies.
Main Results:
- The majority of studies reported significantly enhanced cementum regeneration following treatment with various stem cells.
- Stem cell treatments demonstrated a positive impact on regenerating lost cementum.
Conclusions:
- Clarifying the specific effect of each stem cell type on cementum regeneration in dogs is challenging due to study variations and risk of bias.
- Additional data is required to further analyze the individual effects of stem cells on canine cementum regeneration.
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