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Updated: Feb 11, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

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Advances in CD30- and PD-1-targeted therapies for classical Hodgkin lymphoma

Yucai Wang1, Grzegorz S Nowakowski1, Michael L Wang2

  • 1Division of Hematology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Journal of Hematology & Oncology
|April 25, 2018
PubMed

Insights

Novel targeted therapies, including CD30 antibody-drug conjugates and PD-1 inhibitors, show high efficacy for classical Hodgkin lymphoma (cHL). These treatments offer improved outcomes and reduced toxicity compared to traditional methods.

Area of Science:

  • Oncology
  • Immunotherapy

Background:

  • Classical Hodgkin lymphoma (cHL) management has traditionally relied on chemotherapy and radiotherapy.
  • CD30 and programmed cell death protein 1 (PD-1) are validated therapeutic targets in cHL.

Purpose of the Study:

  • To review the efficacy of targeted therapies in classical Hodgkin lymphoma.
  • To highlight the impact of novel agents on treatment paradigms.

Main Methods:

  • Review of current clinical studies and literature on CD30-targeted therapies and PD-1 inhibitors in cHL.
  • Analysis of treatment outcomes in relapsed/refractory and earlier lines of therapy.

Main Results:

  • Brentuximab vedotin (anti-CD30 ADC) and PD-1 inhibitors (nivolumab, pembrolizumab) demonstrate high efficacy in relapsed/refractory cHL.
  • Early-phase studies show promising results for these agents in earlier treatment lines.

Conclusions:

  • Targeted therapies are transforming cHL management, offering potential for increased cure rates.
  • Emerging treatments are expected to reduce long-term toxicity associated with conventional therapies.

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