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HIV, prospective memory, and cerebrospinal fluid concentrations of quinolinic acid and phosphorylated Tau
Albert M Anderson1, David Croteau2, Ronald J Ellis2
1Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, United States.
Abstract:
There is mounting evidence that prospective memory (PM) is impaired during HIV infection despite treatment. In this prospective study, 66 adults (43 HIV+ and 23 HIV negative) underwent PM assessment and cerebrospinal fluid (CSF) examination. HIV+ participants had significantly lower PM but significantly higher CSF concentrations of CXCL10 and quinolinic acid (QUIN). Higher CSF phosphorylated Tau (pTau) was associated with worse PM. In a secondary analysis excluding outliers, higher QUIN correlated with higher pTau. CSF QUIN is thus elevated during HIV infection despite antiretroviral therapy and could indirectly contribute to impaired PM by influencing the formation of pTau.
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