Related Concept Videos
01:24Intracellular Signaling Cascades
53.7K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.7K
00:54What is Behavior?
10.3K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K
02:56The Fossil Record
27.5K
The fossil record documents only a small fraction of all organisms that have ever inhabited Earth. Fossilization is a rare process, and most organisms never become fossils. Moreover, the fossil record only exhibits fossils that have been discovered. Nevertheless, sedimentary rock fossils of long-lived, abundant, hard-bodied organisms dominate the fossil record. These fossils offer valuable information, such as an organism's physical form, behavior, and age. Studying the fossil record helps...
27.5K
01:08Intracellular Hormone Receptors
59.6K
Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
59.6K
03:06Reaction Mechanisms
31.2K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
31.2K
01:58Mechanical Protein Functions
5.7K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force.
5.7K
You might also read
Related Articles
Articles linked to this work by shared authors, journal, and citation graph.
Sort by
Same author
Humans correctly assign emotional valence of rat vocalizations.
Frontiers in psychology·2026
Same author
Decreased thickness of the individually-mapped genital cortex after childhood sexual abuse exposure in adult women.
Communications biology·2026
Related Experiment Video
Updated: Feb 11, 2026
11:53
Intracellular Recording, Sensory Field Mapping, and Culturing Identified Neurons in the Leech, Hirudo medicinalis
Published on: November 4, 2013
20.6K
Elucidating Neuronal Mechanisms Using Intracellular Recordings during Behavior.
Albert K Lee1, Michael Brecht2
1Howard Hughes Medical Institute (HHMI) Janelia Research Campus, Ashburn, Virginia 20147, USA.
Trends in Neurosciences
|April 25, 2018
Summary
Intracellular recordings offer precise measurements of neuronal membrane potential, revealing cellular mechanisms underlying brain functions like learning and coding. Advances enable these recordings during complex behaviors, enhancing our understanding of neural computations.
Keywords:
behavioral statebirdsongcorollary dischargeexcitabilityfreely movinggain modulationhead-fixedintrinsic propertiesjuxtacellularlearningmembrane potentialnegative imageneuronal integrationneuronal selectivityplace cellplasticityreceptive fieldsharpsparse codingsubthresholdthresholdvirtual realitywhole-cellMore Related Videos
10:29Ablation of a Neuronal Population Using a Two-photon Laser and Its Assessment Using Calcium Imaging and Behavioral Recording in Zebrafish Larvae
Published on: June 2, 2018
9.3K
06:55Simultaneous Recording of Calcium Signals from Identified Neurons and Feeding Behavior of Drosophila melanogaster
Published on: April 26, 2012
16.1K
Area of Science:
- Neuroscience
- Computational Neuroscience
Background:
- Intracellular recording provides high-resolution data on neuronal membrane potential.
- This technique offers insights into cellular properties like excitability and synaptic inputs.
Purpose of the Study:
- To highlight the capabilities of intracellular recording for studying neural mechanisms.
- To discuss advancements enabling in-vivo recordings during complex behaviors.
Main Methods:
- Intracellular recording with sub-millisecond and sub-millivolt precision.
- Integration with genetic and imaging techniques.
- Application in freely moving and head-fixed behaving animals, including virtual reality setups.
Main Results:
- Detailed characterization of individual neuron inputs, outputs, and excitability.
- Elucidation of mechanisms behind brain states, coding, gating, gain modulation, and learning.
- Investigation of neural computations during natural and trained behaviors.
Conclusions:
- Intracellular recording is a powerful tool for understanding neural computations.
- Technical advancements have expanded its applicability to complex behavioral paradigms.
- Combined approaches yield deeper insights into brain function.