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Updated: Feb 11, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Meat allergy and allergens.

Jeffrey M Wilson¹, Thomas A E Platts-Mills¹

¹Division of Allergy & Immunology, University of Virginia, Charlottesville, VA, USA.

Molecular Immunology

|April 25, 2018

Summary

This summary is machine-generated.

Food allergies to meat, including pork-cat syndrome and alpha-Gal syndrome, affect both children and adults. This review covers molecular allergens, sensitization pathways, and diagnostic roles of IgE testing in meat allergy.

Keywords:

Albumin Alpha-Gal Meat allergy Pork-Cat

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Area of Science:

Immunology
Allergology
Gastroenterology

Background:

IgE-mediated hypersensitivity to animal products is a significant food allergy.
Meat allergy affects both children and adults, presenting diverse clinical syndromes.
Pork-cat syndrome and alpha-Gal syndrome highlight unique features of meat allergy.

Purpose of the Study:

To review mammalian and avian meat allergy.
To emphasize molecular allergens and disease pathways.
To discuss the role of in vitro IgE testing in diagnosis and management.

Main Methods:

Literature review of IgE-mediated hypersensitivity to animal products.
Analysis of distinct clinical syndromes within meat allergy.
Examination of molecular allergens, sensitization routes, and diagnostic tools.

Main Results:

Meat allergy is a heterogeneous disorder with distinct syndromes like pork-cat and alpha-Gal syndromes.
Allergy to meat impacts both pediatric and adult populations.
Delayed IgE-mediated reactions and novel sensitization pathways are recognized.

Conclusions:

Understanding meat allergy requires focus on molecular allergens and specific pathways.
In vitro IgE testing is crucial for diagnosing and managing meat allergy.
Further research into sensitization routes and delayed reactions is warranted.