Related Experiment Video
Updated: Feb 11, 2026
Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
Published on: October 22, 2014
Risk factors for recurrence of intussusception in pediatric patients: A retrospective study
Xiaolong Xie, Yang Wu, Qi Wang
1Department of pediatric surgery, West China hospital, Sichuan University, China.
Insights
Children aged two and older, prolonged symptoms over 48 hours, rectal bleeding, left-sided mass location, and pathological lead points increase intussusception recurrence risk. These factors aid in predicting outcomes after treatment.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Clinical Epidemiology
Background:
- Intussusception is a common surgical emergency in children.
- Recurrence after initial reduction poses clinical challenges.
- Identifying risk factors for recurrence is crucial for patient management.
Purpose of the Study:
- To investigate risk factors for intussusception recurrence.
- To analyze predictors of recurrence after operative and nonoperative reduction.
- To inform clinical decision-making and prognostic assessments.
Main Methods:
- Retrospective analysis of pediatric patients with intussusception (2004-2012).
- Inclusion of patients aged 0-18 years undergoing initial reduction (nonoperative or operative).
- Data collection included demographics, symptoms, signs, ultrasound findings, and reduction method.
Main Results:
- Multivariable analysis identified significant risk factors for recurrence.
- Age ≥ 2 years (OR=5.597), duration of symptoms ≥ 48h (OR=91.664), and rectal bleeding (OR=4.758) were key predictors.
- Left-sided mass location (OR=0.038) and pathological lead point (OR=0.002) also significantly influenced recurrence risk.
Conclusions:
- Age, symptom duration, rectal bleeding, mass location, and pathological lead point are significant risk factors for intussusception recurrence.
- These findings can help stratify risk and guide follow-up strategies.
- Further research may explore specific interventions based on these identified risk factors.
Objectives:
The aim of this study was to explore the risk factors associated with recurrence of intussusception after operative or nonoperative reduction in children.
Methods:
Between January 2004 and December 2012, patients with intussusception treated with nonoperative and operative reduction were retrospectively analyzed. We included the patients who were diagnosed with intussusception from the age of 0 year to 18 years who received nonoperative and operative reduction as an initial treatment. The data collected included demographic data (sex, age, and bodyweight), symptoms (vomiting, abdominal pain, rectal bleeding, diarrhea, distention, constipation, and duration of symptoms), signs (temperature, palpable mass, and location of the mass), investigations (ultrasound findings) and the method of reduction.
Results:
The risk factors for recurrence of idiopathic intussusception were analyzed by the univariable analysis and multivariable analysis. In the univariable model, the significant risk factors for recurrence of intussusception analyzed were age, bodyweight, duration of symptoms, rectal bleeding, poor prognosis signs on ultrasound scans, location of mass, and pathological lead point. After multivariable analysis was done, we found that the significant risk factors for recurrence of intussusception were age ≥ 2 years (OR = 5.597, P = 0.044), duration of symptoms ≥48 h (OR = 91.664, P < 0.001), rectal bleeding (OR = 4.758, P = 0.009), location of mass (left over right side) (OR = 0.038, P < 0.001), pathological lead point (OR = 0.002, P < 0.001).
Conclusion:
Our study found that age ≥ 2 years, duration of symptoms≥48 h, rectal bleeding, location of mass (left over right side) and pathological lead point were risk factors for recurrence of intussusception.
Level Of Evidence:
Prognosis study.
Type Of Study:
Retrospective study.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
01:29Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...