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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
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Epigenetics: the first 25 centuries.

A Ganesan1,2

  • 1School of Pharmacy, University of East Anglia, Norwich NR4 7TJ, UK a.ganesan@uea.ac.uk.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|April 25, 2018
PubMed
Summary

Epigenetics explores gene regulation beyond DNA sequence. This issue highlights advances in epigenetic chemical biology and drug discovery for translational research.

Keywords:
epigeneticsgenetics

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Area of Science:

  • Genetics and Molecular Biology
  • Chemical Biology
  • Pharmacology

Background:

  • Epigenetics represents a significant advancement in genetics, focusing on the regulation of genes and heritable elements in eukaryotes.
  • Understanding epigenetic mechanisms is crucial for deciphering complex biological processes.
  • This themed issue stems from a discussion meeting on the frontiers of epigenetic chemical biology.

Observation:

  • The field of epigenetics has seen tremendous recent progress.
  • Interdisciplinary reviews and research articles are presented.
  • Key contemporary issues in epigenetics are addressed.

Findings:

  • Showcases recent advances in epigenetic chemical biology.
  • Highlights translational research in epigenetic drug discovery.
  • Provides a diverse collection of reviews and research articles.

Implications:

  • Advances in epigenetic chemical biology pave the way for novel therapeutic strategies.
  • Translational research in epigenetic drug discovery holds promise for treating various diseases.
  • The interdisciplinary nature of the reviews fosters a holistic understanding of the field.