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Related Experiment Video

Updated: Feb 11, 2026

Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
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Ticagrelor Improves Endothelial Function by Decreasing Circulating Epidermal Growth Factor (EGF).

Francesco Vieceli Dalla Sega1,2,3, Francesca Fortini1,2,3, Giorgio Aquila1,2

  • 1Department of Medical Sciences, University of Ferrara, Ferrara, Italy.

Frontiers in Physiology
|April 25, 2018
PubMed
Summary
This summary is machine-generated.

Ticagrelor improves endothelial function in patients with stable coronary artery disease and chronic obstructive pulmonary disease. It lowers epidermal growth factor (EGF), activating endothelial nitric oxide synthase (eNOS).

Keywords:
EGFchronic obstructive pulmonary disease (COPD)eNOSendothelial functionepidermal growth factor (EGF)stable coronary artery disease (SCAD)ticagrelor

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Area of Science:

  • Cardiology
  • Vascular Biology
  • Pharmacology

Background:

  • Ticagrelor and clopidogrel are P2Y12 inhibitors used in percutaneous coronary intervention (PCI).
  • Previous studies indicated ticagrelor improves endothelial function in patients with Stable Coronary Artery Disease (SCAD) and Chronic Obstructive Pulmonary Disease (COPD) undergoing PCI.
  • Endothelial dysfunction is a key factor in cardiovascular and pulmonary diseases.

Purpose of the Study:

  • To investigate the effect of ticagrelor versus clopidogrel on circulating epidermal growth factor (EGF) levels and endothelial nitric oxide synthase (eNOS) activation.
  • To explore the relationship between EGF, platelet reactivity, and endothelial function.
  • To elucidate the mechanism by which ticagrelor influences endothelial function in SCAD-COPD patients.

Main Methods:

  • A clinical trial comparing ticagrelor and clopidogrel treatment in SCAD-COPD patients undergoing PCI.
  • Measurement of circulating EGF levels and platelet reactivity after one month of treatment.
  • In vitro studies using human umbilical vein endothelial cells (HUVEC) incubated with patient sera.
  • Assessment of p-eNOS levels and eNOS activity in HUVEC.

Main Results:

  • Ticagrelor treatment, unlike clopidogrel, significantly decreased circulating EGF levels.
  • Decreased EGF levels correlated with on-treatment platelet reactivity.
  • Ticagrelor treatment increased p-eNOS levels in HUVEC, suggesting eNOS activation.
  • In vitro, EGF was found to decrease eNOS activity in a dose-dependent manner.

Conclusions:

  • Ticagrelor improves endothelial function by reducing circulating EGF levels.
  • This reduction in EGF leads to the activation of eNOS in the vascular endothelium.
  • The findings provide a mechanistic link between ticagrelor's antiplatelet effect and improved endothelial function in SCAD-COPD patients.