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Phantom Limb Pain in Pediatric Oncology
Patrick DeMoss1, Logan H Ramsey2, Cynthia Windham Karlson3
1Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, United States.
Frontiers in Neurology
|April 25, 2018
Summary
Phantom limb pain (PLP) affects children and adolescents after cancer amputation. Treatments show mixed results, highlighting the need for more research into effective pain management strategies for pediatric cancer survivors.
Area of Science:
- Pediatric Oncology
- Pain Management
- Neuroscience
Background:
- Phantom limb pain (PLP) is a common and distressing issue for pediatric cancer patients post-amputation.
- Symptoms vary widely, from brief sharp pains to constant discomfort, significantly impacting quality of life.
Purpose of the Study:
- To review the characteristics, epidemiology, mechanisms, and evidence-based treatments for PLP in pediatric cancer patients.
- To identify current treatment successes and limitations in managing this specific population.
Main Methods:
- Focused literature review of pediatric PLP, with emphasis on oncology patients.
- Analysis of pharmacologic and non-pharmacologic treatment modalities.
- Examination of chemotherapy as a potential predisposing factor.
Main Results:
- Chemotherapy may sensitize the nervous system, increasing PLP risk in pediatric cancer patients.
- Pharmacologic options like gabapentin and antidepressants have shown mixed success.
- Non-pharmacologic therapies including mirror therapy and psychotherapy demonstrate potential utility.
Conclusions:
- Current treatments for pediatric cancer-related PLP offer mixed success.
- Further prospective controlled trials are essential to establish definitive, evidence-based care guidelines.
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