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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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Immunoglobulin-like Cell Adhesion Molecules01:31

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Receptor-mediated Endocytosis01:20

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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Nonsense-mediated mRNA Decay02:27

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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A Rapid, Simple, and Standardized Homogenization Method to Prepare Antigen/Adjuvant Emulsions for Inducing Experimental Autoimmune Encephalomyelitis
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Immunoglobulin E-Mediated Autoimmunity.

Marcus Maurer1, Sabine Altrichter1, Oliver Schmetzer1

  • 1Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Frontiers in Immunology
|April 25, 2018
PubMed
Summary
This summary is machine-generated.

Immunoglobulin E (IgE) autoantibodies, or autoallergy, are increasingly recognized in autoimmune diseases like lupus and chronic urticaria. Further research is needed to understand their prevalence, relevance, and effects across various conditions.

Keywords:
autoallergybullous pemphigoidimmunoglobulin E-mechanismsimmunoglobulin E-mediated autoimmunityurticaria

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Area of Science:

  • Immunology
  • Autoimmunity
  • Allergy

Background:

  • The role of immunoglobulin E (IgE) autoantibodies in autoimmune diseases, termed autoallergy, is an emerging field.
  • Conditions such as systemic lupus erythematosus, bullous pemphigoid, and chronic urticaria are increasingly linked to IgE autoantibodies.

Purpose of the Study:

  • To review the current literature on IgE-mediated autoallergy.
  • To address the prevalence, relevance, and cellular/molecular effects of IgE autoantibodies in various diseases.
  • To identify knowledge gaps and suggest future research directions.

Main Methods:

  • Comprehensive literature review.
  • Analysis of studies identifying IgE autoantibodies and their targets.
  • Evaluation of therapeutic responses to IgE-targeted treatments.

Main Results:

  • Established IgE autoantibody involvement in bullous pemphigoid (targeting BP180, BP230) and chronic spontaneous urticaria (targeting IL-24).
  • Accumulating evidence suggests IgE autoallergy in other conditions like autoimmune uveitis, rheumatoid arthritis, Graves' disease, and asthma.
  • Therapeutic benefits of anti-IgE treatments are demonstrated in specific autoallergic conditions.

Conclusions:

  • IgE autoallergy is a significant, though developing, area of autoimmune disease research.
  • Identifying specific IgE autoantibodies and targets is crucial for confirming autoallergic mechanisms.
  • Further investigation is required to fully elucidate the role and impact of IgE autoantibodies in diverse autoimmune disorders.