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Prospective Observational Study on acute Appendicitis Worldwide (POSAW).

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This summary is machine-generated.

This study analyzed acute appendicitis (AA) diagnosis and treatment worldwide. Appendectomy remains the primary surgical treatment, with imaging and prognostic scores proving valuable for effective management and low mortality rates.

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Area of Science:

  • General Surgery
  • Surgical Diagnostics
  • Epidemiology

Background:

  • Acute appendicitis (AA) is a common surgical condition requiring accurate diagnosis to minimize unnecessary surgeries.
  • Management of complicated appendicitis presents clinical challenges.
  • Global variations in clinical and diagnostic approaches to AA exist.

Purpose of the Study:

  • To document the worldwide clinical and diagnostic work-up for acute appendicitis.
  • To describe the contemporary management strategies for AA across global surgical departments.

Main Methods:

  • Prospective, multicenter observational study.
  • Involved 116 surgical departments in 44 countries over 6 months (April-September 2016).
  • Included consecutive patients with a clinical diagnosis of AA.

Main Results:

  • 4282 patients (45% female, 55% male, median age 29) were enrolled.
  • Imaging included US (43.3%), CT (21.2%), or both (6.7%).
  • 95.7% underwent surgery (42.2% open appendectomy, 51.7% laparoscopic appendectomy); 4.3% were managed conservatively. Major complications occurred in 4.6%, with a 0.28% mortality rate.

Conclusions:

  • Imaging techniques and prognostic scores are clinically valuable for diagnosing AA.
  • Appendectomy remains the most effective treatment for acute appendicitis.
  • The overall mortality rate for AA is low.