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Published on: March 15, 2024
Invasive Group B streptococcus: multiloculated perinephric abscesses treated with percutaneous drainage
J Isaac Peña-Garcia1, Sana Shaikh1, Alexandre Lacasse1
1Department of Internal Medicine, SSM St. Mary's Hospital - St. Louis, St. Louis, MO, USA.
Abstract:
Group B streptococcus infections (GBSI) are commonly associated with neonates and pregnant women, but may also affect nonpregnant adults. Among its spectrum of manifestations, perinephric abscess (PA) is exceedingly rare. Comorbid conditions such as diabetes mellitus (DM) and immunosuppression increase the risk of GBSI. We describe a 61-year-old Vietnamese man with compensated alcoholic cirrhosis, who presented with acute encephalopathy following subacute, progressive abdominal pain. He was afebrile and hemodynamically stable. Laboratory data were remarkable for leukocytosis, thrombocytopenia, azotemia, and pyuria. He was found to have two right-sided PA measuring 15 × 10 × 11 cm and 4.6 × 2.7 × 7.8 cm, requiring interval placement of multiple percutaneous drains. Culture from abscesses revealed beta-hemolytic Group B streptococcus (GBS). His course was complicated by contiguous spread to abdominal wall and paraspinal musculature, as well as a new diagnosis of type 2 DM. Along with drainage, a prolonged course of intravenous antimicrobial treatment led to abscess resolution. Given the rising number of unusual clinical presentations of GBSI, this bacteria should be considered as a part of the microbiological differential diagnosis of PA, especially in conditions leading to immunosuppression.
Insights
Group B streptococcus (GBS) can cause rare perinephric abscesses (PA) in adults. This case highlights GBS as a differential diagnosis for PA, especially in immunocompromised patients.
Area of Science:
- Infectious Diseases
- Nephrology
- Microbiology
Background:
- Group B streptococcus (GBS) infections are typically seen in neonates and pregnant women.
- Perinephric abscess (PA) is a rare manifestation of GBS infection.
- Comorbidities like diabetes mellitus and immunosuppression increase GBS infection risk.
Observation:
- A 61-year-old man with alcoholic cirrhosis presented with encephalopathy and abdominal pain.
- Imaging revealed two large perinephric abscesses.
- Abscess cultures identified beta-hemolytic Group B streptococcus.
Findings:
- The patient developed complications including abdominal wall and paraspinal muscle spread.
- A new diagnosis of type 2 diabetes mellitus was made.
- Treatment involved abscess drainage and prolonged intravenous antibiotics, leading to resolution.
Implications:
- This case underscores the importance of considering GBS in the differential diagnosis of perinephric abscesses in adults.
- Immunosuppression and conditions like cirrhosis are risk factors for unusual GBS presentations.
- Awareness of GBS as a pathogen for PA is crucial for timely diagnosis and management.
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