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The Neuronal Ischemic Tolerance Is Conditioned by the Tp53 Arg72Pro Polymorphism.

Maria E Ramos-Araque1,2, Cristina Rodriguez1,2, Rebeca Vecino1,2

  • 1Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Calle Zacarías González 2, 37007, Salamanca, Spain.

Translational Stroke Research
|April 25, 2018
PubMed
Summary

Cerebral preconditioning (PC) protects the brain after stroke. The human Tp53 Arg72Pro SNP influences PC neuroprotection, with the Pro72 variant offering better protection by modulating p53 stabilization and improving outcomes in stroke patients with prior TIAs.

Keywords:
Ischemic toleranceNeuroprotectionPreconditioningTp53 Arg72Pro polymorphismTransient ischemic attack

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