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Updated: Feb 11, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Transition-Metal-Catalyzed C-H Functionalization for Construction of Quaternary Carbon Centers
1Department of Chemistry, School of Science and Xi'an Key Laboratory of Sustainable Energy Materials Chemistry, Xi'an Jiaotong University, Xi'an, 710049, P.R. China.
Abstract:
Efficient construction of quaternary carbon centers represents one of the most challenging goals in organic synthesis, and it has drawn tremendous research interest from organic chemist community. The past decade has witnessed a significant advancement of direct C-H functionalization, which delivers various synthetic tools for assembling structurally diversified architectures with the advantage of step- and atom-economy, operational simplicity, and readily available substrates. In this Minireview, synthetic methods based on transition-metal-catalyzed C-H functionalization as efficient tools for the construction of quaternary carbon centers are summarized.
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