Related Experiment Video

Updated: Feb 11, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

11.2K

Can sudden cardiac death in the young be predicted and prevented? Lessons from autopsy for the emergency physician

Jennifer L White1, Anna Marie Chang2, Sergi Cesar3

  • 1Department of Emergency Medicine; Mayo Clinic College of Medicine, Rochester, Minnesota, EE.UU.

Emergencias : Revista De La Sociedad Espanola De Medicina De Emergencias
|April 25, 2018
PubMed

Insights

Sudden cardiac death (SCD) in the young is rare but devastating. Identifying inherited causes is crucial for preventing SCD and avoiding inconclusive autopsies in young individuals.

Area of Science:

  • Cardiology
  • Genetics
  • Forensic Pathology

Background:

  • Sudden unexpected death in the young (SUDY) is a rare but significant cause of mortality.
  • Autopsies for SUDY are often inconclusive, leaving families without answers.
  • Many SUDY cases stem from inherited cardiac conditions, highlighting the need for genetic insights.

Purpose of the Study:

  • To review the causes of sudden cardiac death (SCD) in young individuals.
  • To differentiate between autopsy-positive and autopsy-negative SCD.
  • To explore the role of inherited arrhythmogenic conditions in SCD and discuss predictive/preventive strategies.

Main Methods:

  • Literature review of autopsy findings in young SCD cases.
  • Categorization of SCD causes based on autopsy results (positive vs. negative).
  • Analysis of inherited cardiac conditions associated with SCD.

Main Results:

  • Autopsy-positive SCD in the young is linked to conditions like hypertrophic cardiomyopathy and arrhythmogenic right ventricular dysplasia.
  • Autopsy-negative SCD is frequently associated with inherited arrhythmogenic disorders, including Long QT syndrome, Brugada syndrome, and others.
  • A significant portion of SCD in the young has an inherited basis.

Conclusions:

  • Understanding inherited arrhythmogenic causes is key to diagnosing and managing SCD in the young.
  • Predictive and preventive strategies are essential to reduce SCD incidence and the need for autopsies.
  • Genetic counseling and screening are vital for families affected by SCD.
Abstract

Keywords:
AutopsyAutosomal dominantAutosomal dominant disorderSudden unexpected death

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K
Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment07:49

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

2.1K

Related Concept Videos

Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
379
Emerging Adulthood01:27

Emerging Adulthood

Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
725
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

VSEPR Theory for Determination of Electron Pair Geometries
46.1K
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.2K
Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
3.4K
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K