Long-term Cognitive Outcome of Children With Parenchymal Neurocysticercosis: A Prospective Observation Study

Pratibha Singhi1, Prabhjot Malhi1, Renu Suthar1

  • 11 Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Insights

Neurocysticercosis in children significantly impacts cognitive function and academic achievement. Approximately a fourth of affected children experience cognitive impairment, particularly those from lower socioeconomic backgrounds or with multiple brain lesions.

Area of Science:

  • Neurology
  • Pediatrics
  • Infectious Diseases

Background:

  • Neurocysticercosis, a parasitic infection of the central nervous system, is a significant public health concern, particularly in developing countries.
  • Parenchymal neurocysticercosis can lead to neurological sequelae, including cognitive deficits and epilepsy, affecting children's development and quality of life.

Purpose of the Study:

  • To investigate the cognitive profile and scholastic performance in children diagnosed with parenchymal neurocysticercosis.
  • To identify factors associated with academic underachievement and cognitive impairment in this pediatric population.

Main Methods:

  • A cohort of 500 children with neurocysticercosis and epilepsy was enrolled.
  • Scholastic performance was assessed using school grades.
  • Cognitive function was evaluated through parental interviews and the Draw-a-Man test.

Main Results:

  • Poor scholastic performance was observed in 22.2% of the children.
  • The Draw-a-Man test indicated intellectual quotient (IQ) <70 in 18.2% of assessed children.
  • Intermittent headache, behavioral issues, and memory problems were reported in 40% of cases.
  • Multiple lesions, lower socioeconomic status, and calcified lesions were linked to academic underachievement (P < .05).

Conclusions:

  • A significant proportion of children with neurocysticercosis exhibit cognitive impairment.
  • Children from lower socioeconomic backgrounds and those with multiple neurocysticercosis lesions are at higher risk for cognitive deficits.
  • Early identification and intervention are crucial for mitigating the long-term impact of neurocysticercosis on cognitive development and academic success.

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