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Published on: June 20, 2020
Long-term Cognitive Outcome of Children With Parenchymal Neurocysticercosis: A Prospective Observation Study
Pratibha Singhi1, Prabhjot Malhi1, Renu Suthar1
11 Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Insights
Neurocysticercosis in children significantly impacts cognitive function and academic achievement. Approximately a fourth of affected children experience cognitive impairment, particularly those from lower socioeconomic backgrounds or with multiple brain lesions.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Background:
- Neurocysticercosis, a parasitic infection of the central nervous system, is a significant public health concern, particularly in developing countries.
- Parenchymal neurocysticercosis can lead to neurological sequelae, including cognitive deficits and epilepsy, affecting children's development and quality of life.
Purpose of the Study:
- To investigate the cognitive profile and scholastic performance in children diagnosed with parenchymal neurocysticercosis.
- To identify factors associated with academic underachievement and cognitive impairment in this pediatric population.
Main Methods:
- A cohort of 500 children with neurocysticercosis and epilepsy was enrolled.
- Scholastic performance was assessed using school grades.
- Cognitive function was evaluated through parental interviews and the Draw-a-Man test.
Main Results:
- Poor scholastic performance was observed in 22.2% of the children.
- The Draw-a-Man test indicated intellectual quotient (IQ) <70 in 18.2% of assessed children.
- Intermittent headache, behavioral issues, and memory problems were reported in 40% of cases.
- Multiple lesions, lower socioeconomic status, and calcified lesions were linked to academic underachievement (P < .05).
Conclusions:
- A significant proportion of children with neurocysticercosis exhibit cognitive impairment.
- Children from lower socioeconomic backgrounds and those with multiple neurocysticercosis lesions are at higher risk for cognitive deficits.
- Early identification and intervention are crucial for mitigating the long-term impact of neurocysticercosis on cognitive development and academic success.
Abstract:
To study the cognitive profile and scholastic performance of children with parenchymal neurocysticercosis. A total of 500 children with a diagnosis of neurocysticercosis and epilepsy registered in our pediatric neurocysticercosis clinic between January 1996 and December 2002 were enrolled. Patients were evaluated for their scholastic performance using their school grades. Cognitive assessment was done using Parental interview and the "Draw-a-Man" test. Poor scholastic performance was seen in 22.2% (111) children. Draw-a-Man test was done in 148 children; 18.2% (27/148) had scores equivalent to IQ <70. Intermittent headache, behavior problems, and poor memory were reported in 40% (201) children. Multiple lesions, lower socioeconomic status, and calcified lesions on follow-up were associated with academic underachievement ( P < .05). About a fourth of children with neurocysticercosis had cognitive impairment during follow-up. This was mostly seen in children from lower socioeconomic status and in those with multiple-lesion neurocysticercosis.
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