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The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox

Flora Özkalaycı1, Öykü Gülmez1, Betül Uğur-Altun2

  • 1Department of Cardiology, Başkent University İstanbul Hospital, İstanbul, Turkey

Balkan Medical Journal
|April 25, 2018
PubMed

Insights

Osteoprotegerin plays a key role in cardiovascular disease pathogenesis. This review examines osteoprotegerin

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD) is a leading global cause of death and illness.
  • Risk factors for CVD are well-established, but emerging molecular pathways are increasingly recognized.
  • The receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL), and osteoprotegerin (OPG) system is implicated in bone resorption and potentially cardiovascular pathophysiology.

Purpose of the Study:

  • To review and synthesize current knowledge on the role of osteoprotegerin in cardiovascular disease.
  • To clarify the complex and sometimes conflicting data regarding OPG's impact on the cardiovascular system.

Main Methods:

  • Literature review of existing research on osteoprotegerin and cardiovascular disease.
  • Analysis of studies investigating the association between OPG and cardiovascular pathophysiology.
  • Synthesis of data on OPG's regulatory functions within the cardiovascular system.

Main Results:

  • The OPG system, beyond its role in bone, is increasingly linked to cardiovascular disease.
  • Conflicting data exists regarding the precise impact and regulatory role of OPG in cardiovascular health.
  • OPG's involvement in cardiovascular pathogenesis warrants further investigation.

Conclusions:

  • Osteoprotegerin is a significant factor in cardiovascular disease development.
  • Further research is needed to fully elucidate the mechanisms and clinical implications of OPG in cardiovascular medicine.

Keywords:
Cardiovascular diseaseheartinflammatory markersosteoprotegerin

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