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An extract from amazonian fruit, camu-camu (<i>Myrciaria dubia</i>), attenuates DSS-induced gut-liver axis alterations by improving intestinal morphology and barrier-related gene expression and reducing hepatic histological damage and oxidative stress <i>in ovo</i> (<i>Gallus gallus</i>).

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Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes
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Retraction: ZnO nanoparticles affect intestinal function in an in vitro model.

Fabiola Moreno-Olivas1, Elad Tako, Gretchen J Mahler

  • 1Department of Biomedical Engineering, Binghamton University, Binghamton, NY 13902, USA. gmahler@binghamton.edu.

Food & Function
|April 25, 2018
PubMed
Summary

This retraction notice concerns a study on zinc oxide nanoparticles and intestinal function. The original article is no longer considered valid due to undisclosed conflicts of interest.

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Area of Science:

  • Nanotechnology
  • Gastroenterology
  • Toxicology

Background:

  • Zinc oxide nanoparticles (ZnO NPs) are increasingly used in various consumer products.
  • Understanding their potential impact on gastrointestinal health is crucial.
  • Previous research suggested effects on intestinal function.

Purpose of the Study:

  • To investigate the effects of ZnO NPs on intestinal epithelial cells in vitro.
  • To assess the impact on key intestinal functions like barrier integrity and transport.

Main Methods:

  • Utilized an in vitro intestinal model (e.g., Caco-2 cell monolayers).
  • Exposed cells to varying concentrations of ZnO NPs.
  • Assessed parameters such as transepithelial electrical resistance (TEER) and marker expression.

Main Results:

  • The original study reported that ZnO NPs altered intestinal function.
  • Specific findings related to changes in cell permeability and enzyme activity were presented.

Conclusions:

  • The original conclusions regarding ZnO NP effects on intestinal function are retracted.
  • This retraction impacts the understanding of nanoparticle safety in the gastrointestinal tract.