Related Experiment Video

Updated: Feb 11, 2026

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors
05:18

Derivation of Leptomeninges Explant Cultures from Postmortem Human Brain Donors

Published on: January 21, 2017

8.7K

Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia

Helene A Fachim1, Umarat Srisawat1, Caroline F Dalton1

  • 1Biomolecular Sciences Research Center, Sheffield Hallam University, Sheffield, UK.

Epigenomics
|April 25, 2018
PubMed

Keywords:
DNA methylationLINE-1parvalbuminpostmortem brainschizophrenia

More Related Videos

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue10:58

Neuronal Nuclei Isolation from Human Postmortem Brain Tissue

Published on: October 1, 2008

22.6K
Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue18:17

Obtaining High Quality RNA from Single Cell Populations in Human Postmortem Brain Tissue

Published on: August 6, 2009

31.1K

Related Concept Videos

Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.0K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
656
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
645
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
18.9K
The Eukaryotic Promoter Region02:40

The Eukaryotic Promoter Region

4.0K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
635