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Related Experiment Video

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High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

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Screening for confabulations with the confabulation screen.

Gianfranco Dalla Barba^1,2,3,4, Marta Brazzarola⁴, Sara Marangoni⁴

¹INSERM, Paris, France.

Neuropsychological Rehabilitation

|April 25, 2018

Summary

A new screening test for confabulation, the Confabulation Screen (CS), effectively identifies confabulatory impairment in episodic memory (EM) and personal temporality. The CS demonstrates high validity and discriminative power for clinical and research use.

Keywords:

Amnesia Confabulation Memory

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Area of Science:

Neuropsychology
Cognitive Psychology
Neurology

Background:

Confabulation is a memory disturbance common in various neurological conditions.
Existing methods for assessing confabulation can be time-consuming and lack specificity.
Episodic memory (EM) is a key domain where confabulations frequently occur.

Purpose of the Study:

To develop and validate a sensitive and specific screening test for confabulatory impairment.
To assess the Confabulation Screen's (CS) ability to predict confabulations across different personal temporality domains.
To establish the construct and discriminative validity of the CS.

Main Methods:

Development of the Confabulation Screen (CS), a 10-question episodic memory (EM) test.
Administration of the CS and the Confabulation Battery (CB) to 30 confabulating amnesic patients and 97 controls.
Correlation analysis to assess the relationship between CS confabulations and confabulations in various CB domains.

Main Results:

Confabulations on the CS significantly correlated with confabulations in personal temporality domains (EM, orientation, episodic plans) of the CB.
No significant correlation was found between CS confabulations and impersonal temporality domains.
Habits Confabulation was the most frequent type observed in the CS, consistent with prior research.

Conclusions:

The Confabulation Screen (CS) is a valid and efficient tool for screening confabulatory impairment.
The CS demonstrates high construct validity and good discriminative validity (sensitivity and specificity).
Proposed cut-off scores facilitate clinical and research applications of the CS.