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Related Concept Videos

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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What is Gene Expression?01:36

What is Gene Expression?

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
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mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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Global Gene Expression Analysis Using a Zebrafish Oligonucleotide Microarray Platform
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CellExpress: a comprehensive microarray-based cancer cell line and clinical sample gene expression analysis online

Yi-Fang Lee1, Chien-Yueh Lee1, Liang-Chuan Lai2

  • 1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.

Database : the Journal of Biological Databases and Curation
|April 25, 2018
PubMed
Summary

CellExpress is a comprehensive database for cell-specific gene expression. It provides valuable insights into gene regulation across various cell types, aiding research in cell biology and genomics.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Cell Biology

Background:

  • Understanding gene expression patterns is crucial for deciphering cellular functions.
  • Existing databases may lack comprehensive coverage or user-friendly interfaces for cell-specific data.

Purpose of the Study:

  • To introduce CellExpress, a novel database for cell-specific gene expression.
  • To provide researchers with an accessible platform for exploring gene regulation in diverse cell types.

Main Methods:

  • Data collection from public repositories.
  • Development of a structured database schema.
  • Implementation of a web-based interface for data querying and visualization.

Main Results:

  • CellExpress integrates gene expression data from multiple sources.
  • The database offers advanced search functionalities for cell types and genes.
  • Includes tools for analyzing expression patterns and regulatory networks.

Conclusions:

  • CellExpress serves as a valuable resource for cell-specific gene expression research.
  • Facilitates the discovery of novel gene functions and regulatory mechanisms.
  • Supports interdisciplinary research in biology and medicine.