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Related Concept Videos

Peptide Bonds02:43

Peptide Bonds

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
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Isomerism in Complexes
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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
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Patterning Bioactive Proteins or Peptides on Hydrogel Using Photochemistry for Biological Applications
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StraPep: a structure database of bioactive peptides.

Jian Wang1, Tailang Yin2, Xuwen Xiao3

  • 1Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.

Database : the Journal of Biological Databases and Curation
|April 25, 2018
PubMed
Summary

This study introduces StraPep, a novel database for exploring peptide structures and their interactions. StraPep provides valuable insights into peptide research and drug discovery.

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Area of Science:

  • Structural biology
  • Bioinformatics
  • Computational chemistry

Background:

  • Peptides play crucial roles in biological processes.
  • Understanding peptide structure-activity relationships is vital for drug discovery.
  • Existing databases lack comprehensive structural and interaction data for peptides.

Purpose of the Study:

  • To develop and present StraPep, a centralized, curated database for peptide structural information.
  • To facilitate the exploration of peptide structures, properties, and interactions.
  • To support research in peptide-based therapeutics and biomaterials.

Main Methods:

  • Data collection from PDB and other sources.
  • Development of a web-based platform for data access and visualization.
  • Implementation of structure analysis and property prediction algorithms.

Main Results:

  • StraPep houses a diverse collection of peptide structures.
  • The database offers tools for structure visualization, similarity searching, and property analysis.
  • Integration of experimental and predicted structural data.

Conclusions:

  • StraPep serves as a valuable resource for the scientific community.
  • The database can accelerate research in peptide science and drug development.
  • Future updates will expand the scope and functionality of StraPep.