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Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key...

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Updated: Feb 11, 2026

Single-Molecule FRET Imaging for Observing the Conformational Dynamics of Dynamin-Like GTPase Atlastin

Single-Molecule FRET Imaging for Observing the Conformational Dynamics of Dynamin-Like GTPase Atlastin

Published on: January 24, 2025

The dynamin superfamily.

Rajesh Ramachandran¹, Sandra L Schmid²

¹Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Current Biology : CB

|April 25, 2018

Summary

This summary is machine-generated.

The dynamin superfamily, a group of large GTPases, self-assemble into dynamic polymeric arrays. Their activity is regulated by an autonomous, assembly-stimulated GTPase function, distinguishing them from other GTPase families.

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Area of Science:

Molecular Biology
Biochemistry
Cell Biology

Background:

The dynamin superfamily is a diverse group of GTPases found across many species.
These proteins are characterized by their modular structure, large size, and low nucleotide affinity.

Purpose of the Study:

To highlight the unique characteristics of the dynamin superfamily.
To describe their self-assembly and GTPase activity.

Main Methods:

Structural analysis of dynamin superfamily proteins.
Biochemical assays to study GTPase activity.
Observation of self-assembly into polymeric arrays.

Main Results:

Dynamins possess a modular structure, distinguishing them from Ras, Rab, and G-protein families.
They exhibit low affinity for guanine nucleotides.
A conserved propensity for self-assembly into polymeric arrays was observed.
Assembly-stimulated GTPase activity regulates the dynamics of these arrays.

Conclusions:

The dynamin superfamily represents a unique class of GTPases with distinct structural and functional properties.
Their self-assembly and regulated GTPase activity are key features of their biological roles.