Prevalence of Celiac Disease in Patients With Iron Deficiency Anemia-A Systematic Review With Meta-analysis

Related Experiment Video

Updated: Feb 11, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Srihari Mahadev1, Monika Laszkowska1, Johan Sundström2

  • 1Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.

Gastroenterology
|April 25, 2018
PubMed

Insights

Approximately 1 in 31 individuals with iron-deficiency anemia (IDA) have celiac disease (CD). This systematic review confirms that screening IDA patients for CD is warranted, supporting current clinical guidelines.

Area of Science:

  • Gastroenterology
  • Internal Medicine
  • Clinical Diagnostics

Background:

  • Anemia, particularly iron-deficiency anemia (IDA), is frequently observed in patients with celiac disease (CD).
  • Current medical guidelines advocate for screening individuals with IDA for CD.
  • The precise prevalence of CD among IDA patients remains variable in existing literature.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis to determine the prevalence of biopsy-verified celiac disease (CD) in patients presenting with iron-deficiency anemia (IDA).

Main Methods:

  • A systematic literature search was performed using PubMed Medline and EMBASE databases up to July 2017.
  • Studies were identified using keywords "celiac disease" combined with "anemia" or "iron deficiency."
  • Fixed-effects inverse variance-weighted models were employed to calculate the pooled prevalence of CD, with meta-regression used to analyze heterogeneity.

Main Results:

  • The analysis included 18 studies encompassing 2998 patients with IDA, with CD prevalence identified in 4.8% (unweighted) and 3.2% (weighted pooled analysis).
  • High heterogeneity (I² = 67.7%) was noted, but subgroup analyses and meta-regression did not reveal significant associations with age, sex, or publication year.
  • In 8 high-quality studies, the pooled prevalence of biopsy-confirmed CD was 5.5% (95% CI = 4.1-6.9).

Conclusions:

  • This systematic review and meta-analysis indicates that approximately 1 in 31 patients with IDA have biopsy-confirmed celiac disease.
  • The findings support the established clinical practice of screening patients with iron-deficiency anemia for celiac disease.
Abstract

Keywords:
CeliacCoeliacIron DeficiencyMeta-Analysis

More Related Videos

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

20.5K
Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

2.4K

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.9K
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.6K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.2K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.4K