Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

339
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
339
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

189
Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
189
Cartesian Form for Vector Formulation01:26

Cartesian Form for Vector Formulation

1.1K
The Cartesian form for vector formulation is a process to calculate  the moment of force using the position and force vectors. The moment of force is defined as the cross-product of these vectors, making it a vector quantity. The Cartesian form of the position and force vectors involves unit vectors, which can be used to express the cross-product in determinant form.
1.1K
Resultant Moment: Vector Formulation01:30

Resultant Moment: Vector Formulation

3.9K
When a force is applied to an object, the tendency of the object to rotate about a point is known as its moment. If multiple forces are acting on an object, the sum of moments of all the forces acting on a body can be expressed as the resultant moment of the system. The resultant moment can be considered a vector quantity that can be added and subtracted like any other vector.
The resultant moment of a system of forces can be calculated through vector formulation. For example, if we consider...
3.9K
Couples: Scalar and Vector Formulation01:21

Couples: Scalar and Vector Formulation

645
One might wonder how the captain of a large ship can navigate through the ocean with just a turn of the steering wheel. The answer lies in the concept of two parallel forces that are equal in magnitude and opposite sense, creating a couple moment.
A couple moment is a rotational force that tends to rotate the steering wheel. The wheel's rotation can either be in a clockwise or anticlockwise direction. The right-hand rule is a helpful method for determining the direction of a couple moment....
645
Formulating and Validating Nursing Diagnosis I01:26

Formulating and Validating Nursing Diagnosis I

4.0K
A nursing diagnosis is written when the nurse recognizes a cluster of essential patient data indicating health problems treated with independent nursing interventions. The standardized terminologies of a nursing diagnosis help nurses identify and treat patients' problems. Every electronic health record that uses nursing diagnosis must employ standard diagnostic terminology. Developing an efficient, individualized care plan begins with accurate nursing diagnoses.
There are thirteen domains...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antibody-Drug Conjugates: Pharmacotherapeutic Properties and Future Perspectives.

Pharmaceutics·2026
Same author

Predictive value of the hERG assay for anticipating the arrhythmogenic potential of new drugs.

Drug discovery today·2026
Same author

Co-encapsulation in Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as an Emerging Therapeutic Strategy.

Molecular diagnosis & therapy·2026
Same author

Targeting Trypanothione Synthetase and Trypanothione Reductase: Development of Common Inhibitors to Tackle Trypanosomatid Disease.

Pharmaceuticals (Basel, Switzerland)·2025
Same author

Artificial intelligence in pharmacovigilance: a narrative review and practical experience with an expert-defined Bayesian network tool.

International journal of clinical pharmacy·2025
Same author

Enhancing Acute Migraine Treatment: Exploring Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for the Nose-to-Brain Route.

Pharmaceutics·2024

Related Experiment Video

Updated: Feb 11, 2026

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.1K

Cyclodextrins as excipients in tablet formulations.

Jaime Conceição1, Oluwatomide Adeoye2, Helena Maria Cabral-Marques3

  • 1UCIBIO - ReQuimTe, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Oporto, Portugal.

Drug Discovery Today
|April 25, 2018
PubMed
Summary

This review covers cyclodextrins as pharmaceutical excipients in tablet formulations. It details their applications, formulation technologies, and regulatory status, offering insights for drug development.

More Related Videos

Formulations for Freeze-drying of Bacteria and Their Influence on Cell Survival
08:55

Formulations for Freeze-drying of Bacteria and Their Influence on Cell Survival

Published on: August 3, 2013

24.4K
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.8K

Related Experiment Videos

Last Updated: Feb 11, 2026

Formation of Dispersible Taohong Siwu Tablets
05:44

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

2.1K
Formulations for Freeze-drying of Bacteria and Their Influence on Cell Survival
08:55

Formulations for Freeze-drying of Bacteria and Their Influence on Cell Survival

Published on: August 3, 2013

24.4K
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

10.8K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Cyclodextrins are widely used pharmaceutical excipients.
  • Their application in tablet formulations is diverse.

Purpose of the Study:

  • To critically review cyclodextrins as excipients in tablet formulations.
  • To highlight their pharmaceutical applications, technological aspects, and regulatory status.

Main Methods:

  • Literature review of cyclodextrin applications in tablet formulations.
  • Analysis of technological aspects in pharmaceutical formulation development.
  • Review of the regulatory status of cyclodextrins.

Main Results:

  • Cyclodextrins serve as complexing excipients for low-dose drugs.
  • Methods to enhance complexation efficiency are crucial for medium-dose drugs.
  • Cyclodextrins also function as fillers, disintegrants, binders, and direct compression excipients.

Conclusions:

  • Cyclodextrins offer versatile applications in tablet formulations.
  • Optimization of complexation is key for efficient drug delivery.
  • Understanding their technological and regulatory aspects is vital for successful drug product development.