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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

The relationship between interleukin-6 and functional connectivity in methamphetamine users.

Milky Kohno¹, Jennifer M Loftis², Marilyn Huckans³

¹Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA; Research & Development Service, Veterans Affairs Portland Health Care System, 3710 SW US Veterans Hospital Road, Portland, OR, USA; Methamphetamine Abuse Research Center, Oregon Health & Science University and Veterans Affairs Portland Health Care System, Portland, OR, USA.

Neuroscience Letters

|April 25, 2018

Summary

This summary is machine-generated.

Methamphetamine addiction is linked to inflammation. Higher interleukin-6 (IL-6) levels correlated with altered brain connectivity in methamphetamine-dependent individuals, suggesting inflammation

Keywords:

Corticostriatal IL-6 Inflammation Mesocorticolimbic Methamphetamine Resting-state functional connectivity

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Area of Science:

Neuroscience
Psychiatry
Immunology

Background:

Methamphetamine (MA) use is associated with increased pro-inflammatory cytokines.
Neuroinflammation, driven by microglia activation, may influence addiction-related behaviors via reward pathways.
Understanding the role of specific cytokines like interleukin-6 (IL-6) in brain connectivity is crucial for addiction research.

Purpose of the Study:

To investigate the relationship between plasma interleukin-6 (IL-6) levels and resting-state functional connectivity (RSFC) in the corticolimbic and striatolimbic networks.
To explore how IL-6 interacts with group status (MA dependence vs. controls) to affect brain connectivity.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) was conducted on 30 adults with MA dependence and 20 healthy controls.
Plasma IL-6 levels were measured.
Seed-based RSFC analyses were performed, focusing on ventral striatal and prefrontal regions.

Main Results:

In the MA group, higher IL-6 levels were positively associated with striatolimbic RSFC.
Conversely, higher IL-6 levels were negatively associated with corticostriatal RSFC within the MA group.
These associations were specific to the MA-dependent individuals.

Conclusions:

Findings suggest that IL-6-related inflammation may mediate the association between MA use disorder, altered brain connectivity, and behavioral aspects of addiction.
The results support a role for inflammatory processes, potentially impacting mesolimbic and mesocortical dopaminergic systems, in the neurobiology of methamphetamine addiction.