Related Experiment Video
Updated: Feb 11, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
A theranostic nanocomposite system based on iron oxide-drug nanocages for targeted magnetic field responsive
Mookkandi Palsamy Kesavan1, Niranjan G Kotla2, Srinivasan Ayyanaar1
1Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Ramanathapuram (D.T.), Tamilnadu, India.
Abstract:
In this work, a theranostic nanocage system was developed for the targeted delivery of the anti-cancer agents camptothecin (CPT) and luotonin A (LuA). The core of the nanocage system (Fe3O4@OA-AD-SP NCs) was formed by biogenically synthesized Fe3O4 nanoparticles (NPs) decorated with a model anti-cancer drug (AD) and biosurfactant saponin (SP). The Fe3O4@OA-AD-SP NCs showed a high lipophilic AD loading efficiency (>80%) and a controlled pH-responsive drug release in stimulated cancerous cells in pH 6.4 media buffer. In addition, Fe3O4@OA-AD-SP NCs exhibited better serum protein binding efficacy at physiological pH values (7.4), furthering the important role of SP surface decoration. Particularly, these NCs showed better chemotherapeutic efficacy when examined in MCF-7 and HeLa cancer cell lines with a specific targeting capacity. Therefore, this study provides a new nano platform based on magnetic targeting and pH responsive lipophilic anticancer drug delivery to the cancer site.
Related Concept Videos
Magnetic Fields
A magnetic field is defined by the force that a charged particle experiences...
Magnetic Field of a Solenoid
Consider a solenoid with 100 turns wrapped around a cylinder of...
Magnetic Field Lines
Magnetic field lines follow several hard-and-fast rules:
Energy In A Magnetic Field
Take an ideal inductor with zero resistance. Although it's practically impossible, assume that the coil's resistance is so small that it is practically negligible. The loss of the field's energy to dissipate thermal energy (or heat) is thus...
Magnetic Field Of A Current Loop
Magnetic Field due to Moving Charges
Consider a point charge moving with a constant velocity. Like the electric field, the magnetic field at any point is directly proportional to the magnitude of the charge and inversely proportional to the square of the distance between the source point and the field point. However, unlike the electric field, the magnetic field is always perpendicular to the plane containing the line...

