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Related Experiment Video

Updated: Feb 11, 2026

Conducting Multiple Imaging Modes with One Fluorescence Microscope

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Published on: October 28, 2018

A continuous control mode with improved imaging rate for scanning ion conductance microscope (SICM).

Jian Zhuang¹, Yangbohan Jiao¹, Zeqing Li¹

¹School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China; Key Laboratory of Education Ministry for Modern Design Rotor-Bearing System, Xi'an Jiaotong University, Xi'an 710049, China.

Ultramicroscopy

|April 25, 2018

Summary

A new continuous control mode for Scanning Ion Conductance Microscopy (SICM) significantly speeds up imaging. This advancement overcomes limitations of the stepwise mode, enabling faster, high-resolution 3D surface characterization of diverse materials and biological samples.

Keywords:

Continuous control mode Imaging rate Mean square error (MSE)Pixel detection frequency Scanning ion conductance microscope (SICM)Stepwise approach mode

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Area of Science:

Surface science
Microscopy techniques
Materials characterization

Background:

Scanning Ion Conductance Microscopy (SICM) offers high-resolution 3D imaging, ideal for soft materials.
The conventional stepwise control mode of SICM is time-consuming due to repeated acceleration and deceleration, limiting its application for dynamic processes.

Purpose of the Study:

To develop a fast control mode for SICM to overcome imaging speed limitations.
To enhance the imaging rate and reliability of SICM without compromising resolution.

Main Methods:

Developed a continuous control mode for SICM, where the probe moves based on speed instructions.
Compared the continuous control mode with the conventional stepwise control mode using soft polymer (PDMS), hard metal grating, and biological (cardiac fibroblast) samples.

Main Results:

The continuous control mode achieved significantly faster approach speeds (up to 300 nm/ms) compared to the stepwise mode.
Continuous control reduced imaging deviation, improved scanning rates, and provided more stable topography reconstruction.
High-resolution 3D imaging was maintained, demonstrating suitability for various sample types.

Conclusions:

The developed continuous control mode offers an efficient and reliable strategy to enhance SICM imaging performance.
This advancement enables potential applications in dynamic characterizations across material science, biology, and chemistry.