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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Preparation, characterization and molecular modeling studies of the beta-cyclodextrin inclusion complex with
K Sivakumar1, G Parinamachivayam1, M Murali Krishnan2
1Department of Chemistry, Faculty of Science, Sri Chandrasekharendra Saraswathi Viswa Mahavidyalaya University (SCSVMV University), Enathur, Kanchipuram 631 561, Tamilnadu, India.
Abstract:
The inclusion complex of β-cyclodextrin (β-CD) with benzoguanamine (BGA) has been investigated in three states. UV-Visible and fluorescence spectral techniques are used in liquid state. FTIR, NMR and MASS techniques are used in solid state and virtual state studies are done by molecular simulation work. The binding constants for the formation of 1:1 BGA:β-CD inclusion complex is estimated by UV-Visible and fluorescence spectral techniques. The chemosensory ability of BGA:β-CD complex was investigated thoroughly for various metal cations and we found the emission of complex showed a linear increase in the intensity for Ce4+ with the linearity range of 1000 μM-2000 μM. Sensitivity analysis shows good sensing for Ce4+ with the LOD of 671 μM and LOQ of 2034 μM. Our result suggests that the BGA:β-CD inclusion complex would be promising material for developing solid state sensory device for sensing Ce4+.
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