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Decreased Circulating Insulin-Like Growth Factor 1 Levels Are Associated with Cardiac Diastolic Dysfunction in Small

Yohei Akazawa1, Shoko Yamazaki1, Haruka Obinata1

  • 1Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

American Journal of Perinatology
|April 25, 2018
PubMed

Insights

Serum insulin-like growth factor-1 (IGF-1) levels were lower in small for gestational age (SGA) infants, correlating with impaired cardiac function. Lower IGF-1 may contribute to diastolic dysfunction in SGA infants.

Area of Science:

  • Neonatal physiology
  • Pediatric cardiology
  • Endocrinology

Background:

  • Small for gestational age (SGA) infants are at risk for various health issues, including potential cardiac complications.
  • Insulin-like growth factor-1 (IGF-1) plays a crucial role in fetal and postnatal growth and development.
  • Cardiac function in SGA infants requires further investigation to understand underlying mechanisms.

Purpose of the Study:

  • To evaluate the impact of serum insulin-like growth factor-1 (IGF-1) levels on cardiac function in small for gestational age (SGA) infants.
  • To compare cardiac function parameters between SGA and appropriate for gestational age (AGA) infants.
  • To determine the correlation between serum IGF-1 levels and cardiac function in SGA infants.

Main Methods:

  • Prospective, observational study design.
  • Serum IGF-1 levels measured at birth in SGA and AGA infants.
  • Echocardiography, including tissue Doppler imaging (TDI) for mitral annular velocities (S' and E'), performed at 1 week of age.
  • Statistical analysis including correlation and multivariate regression.

Main Results:

  • SGA infants exhibited significantly lower serum IGF-1 levels compared to AGA infants.
  • SGA infants showed reduced mitral lateral annular systolic (S') and early diastolic (E') TDI velocities.
  • Serum IGF-1 levels positively correlated with E' velocity in both the entire cohort and SGA infants.
  • Serum IGF-1 and S' velocity were independently associated with E' velocity in SGA infants.

Conclusions:

  • Decreased serum IGF-1 levels are observed in SGA infants.
  • Lower IGF-1 levels are associated with impaired cardiac diastolic function (reduced E' velocity) in SGA infants.
  • Serum IGF-1 may play a role in the development of cardiac diastolic dysfunction in SGA infants.
Abstract

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