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Streptococcus pneumoniae: distribution of serotypes and antimicrobial susceptibility in patients with cancer

Araceli Soto-Noguerón1, María Noemí Carnalla-Barajas1, Patricia Cornejo-Juárez2

  • 1Departamento de Evaluación de Vacunas, Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México.

Salud Publica De Mexico
|April 25, 2018
PubMed
Abstract

Insights

Pneumococcal serotypes causing infections in cancer patients shifted after PCV7 introduction in Mexico, with an increase in non-vaccine types but no significant changes in antimicrobial susceptibility.

Area of Science:

  • Infectious Diseases
  • Oncology
  • Microbiology

Background:

  • Hematological malignancies and solid tumors increase susceptibility to infections.
  • Pneumococcal infections pose a significant threat to immunocompromised patients.
  • The pneumococcal conjugate vaccine (PCV7) was introduced in Mexico to prevent pneumococcal diseases.

Purpose of the Study:

  • To determine the distribution of pneumococcal serotypes in patients with hematological malignancies and solid tumors.
  • To assess antimicrobial susceptibility patterns before and after PCV7 introduction in Mexico.
  • To identify changes in serotype prevalence and resistance following vaccination.

Main Methods:

  • Collected and serotyped 175 consecutive pneumococcal isolates from hospitalized patients using the Quellung reaction.
  • Assessed antimicrobial susceptibility via broth microdilution.
  • Analyzed data from the SIREVA-network.

Main Results:

  • Serotypes 19A, 19F, and 35B were most common in hematological malignancy patients.
  • Serotypes 3 and 19A predominated in solid tumor patients.
  • No decreased susceptibility to beta-lactams or TMP/SMX was observed post-PCV7.

Conclusions:

  • PCV7 introduction in Mexico led to an increase in non-vaccine pneumococcal serotypes.
  • Antimicrobial susceptibility remained largely unchanged after PCV7 implementation.
  • Continued surveillance is crucial for monitoring pneumococcal epidemiology in vulnerable populations.
Keywords:
Streptococcus pneumoniaeantiinfective agentscancervaccines

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