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Low miR-192 expression predicts poor prognosis in pediatric acute myeloid leukemia

Chunmei Tian1, Lin Zhang2, Xiaohua Li1

  • 1Department of Pediatrics, Affiliated Hospital of Binzhou Medical University, Binzhou 256603, Shandong, China.

Cancer Biomarkers : Section a of Disease Markers
|April 26, 2018
PubMed
Abstract

Insights

Serum miR-192 is downregulated in pediatric acute myeloid leukemia (AML) and serves as a potential biomarker for diagnosis and prognosis. Low levels indicate a poorer outcome in pediatric AML patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarkers

Background:

  • miR-192 abnormal expression is noted in various cancers.
  • Its role in pediatric acute myeloid leukemia (AML) remains unclear.

Purpose of the Study:

  • To investigate miR-192 expression in pediatric AML.
  • To determine its clinical significance and prognostic value.

Main Methods:

  • Quantitative RT-PCR used to measure serum miR-192 levels.
  • Compared 97 pediatric AML cases with 50 healthy controls.

Main Results:

  • Serum miR-192 was downregulated in pediatric AML patients.
  • Downregulation correlated with aggressive clinical features and poor prognosis.
  • miR-192 showed diagnostic potential and acted as an independent prognostic indicator.

Conclusions:

  • Serum miR-192 is a potential biomarker for pediatric AML diagnosis.
  • It can predict prognosis and survival outcomes in pediatric AML.
Keywords:
Acute myeloid leukemiaMiR-192pediatricprognosis

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