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Updated: Feb 11, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Extravasation of total parenteral nutrition into the liver from an upper extremity peripherally inserted central
Arpit Gupta1,2, Alok Bhutada2, Miheret Yitayew2
1Division of Neonatology, Maimonides Infants and Children's Hospital, Brooklyn, NY, USA.
Abstract:
Peripherally inserted central catheters (PICC) are the mainstay of central venous access in preterm infants, and one of the common procedures performed in neonatal intensive care unit (NICU). Complications of PICC include infection, mechanical dysfunction, thrombosis, migration, and extravasation of the infusate. In this report, we describe a case of PICC inserted from an upper extremity with migration into the inferior vena cava (IVC) and the hepatic vein associated with extravasation of the total parenteral nutrition (TPN) into the peritoneum and the liver. This case highlights the vigilance required not only to insert but for the maintenance of PICC to prevent complications associated with migration of PICC.
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