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Intravenous Injections in Neonatal Mice
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Forebrain cellular bioenergetics in neonatal mice.

Hassib Narchi1, Pramathan Thachillath1, Abdul-Kader Souid1

  • 1Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, United Arab Emirates.

Journal of Neonatal-Perinatal Medicine
|April 26, 2018
PubMed
Summary

Neonatal brain cells rely more on glucose for energy. Young pups show reduced cellular respiration and adenosine triphosphate (ATP) decay, explaining their vulnerability to hypoglycemia.

Keywords:
Hypoglycemia, neonatescellular ATP, BALB/c micecellular bioenergeticscellular respiration

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Area of Science:

  • Neonatal neuroscience
  • Cellular bioenergetics
  • Metabolic regulation

Background:

  • Hypoglycemia is common in neonates and can cause neurologic dysfunction.
  • The effects of hypoglycemia on neonatal brain cellular respiration and bioenergetics are not well understood.

Purpose of the Study:

  • To develop a murine model for investigating the impact of hypoglycemia on neonatal brain bioenergetics.
  • To compare cellular respiration and adenosine triphosphate (ATP) levels in neonatal and older mouse brains under varying glucose conditions.

Main Methods:

  • Forebrain tissue was collected from BALB/c pups aged 0–14 days.
  • Cellular respiration was measured using a phosphorescence oxygen analyzer.
  • Cellular adenosine triphosphate (ATP) levels were quantified using the luciferin-luciferase system.

Main Results:

  • Younger pups (≤3 days) showed significantly lower respiration when relying on endogenous fuels (without added glucose) compared to older pups (3–14 days).
  • ATP content was similarly depleted in both age groups without glucose, but younger pups exhibited a slower rate of ATP decay.
  • This indicates a greater dependence on exogenous glucose for energy in the neonatal brain.

Conclusions:

  • Neonatal forebrain cellular respiration and ATP consumption are lower than in older mice.
  • Reduced reliance on endogenous fuels and slower ATP turnover in young pups contribute to their heightened sensitivity to hypoglycemia.
  • These findings highlight the critical role of glucose in supporting neonatal brain energy metabolism.