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Subacute infantile mountain sickness.

G J Sui1, Y H Liu, X S Cheng

  • 1Department of Pathology, People's Hospital of the Tibetan Autonomous Region, People's Republic of China, Lhasa.

The Journal of Pathology
|June 1, 1988
PubMed
Summary
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Infants moved to high-altitude Lhasa, Tibet, develop a severe, often fatal pulmonary vascular disease. This condition, distinct from typical mountain sickness, involves significant heart and lung changes.

Area of Science:

  • Pediatric Medicine
  • Cardiovascular Physiology
  • High-Altitude Research

Background:

  • Infants born at low altitudes and moved to high altitudes (3600 m) in Lhasa, Tibet, are susceptible to a severe disease.
  • This condition typically results in fatality within weeks to months of relocation.

Purpose of the Study:

  • To describe a unique pediatric disease observed in high-altitude Lhasa, Tibet.
  • To differentiate this disease from known altitude-related illnesses.
  • To identify the pathological characteristics of this infant disease.

Main Methods:

  • Clinical observation of affected infants in Lhasa.
  • Pathological examination of pulmonary arteries and cardiac structures.
  • Comparison with known high-altitude maladies and animal diseases.

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Main Results:

  • The disease is characterized by extreme medial hypertrophy of muscular pulmonary arteries and pulmonary arterioles.
  • Dilatation of the pulmonary trunk and significant hypertrophy and dilatation of the right ventricle are observed.
  • The condition is pathologically distinct from acute and chronic mountain sickness.

Conclusions:

  • This infant disease in Lhasa represents a severe form of high-altitude pulmonary vascular pathology.
  • It is suggested to be the human equivalent of brisket disease seen in cattle.
  • Prompt recognition and further research are crucial for understanding and potentially managing this condition.